ABC transporters

Parent categories	1. Cellular processes 1.2. Transporters
Neighbouring categories	1.2.1. ABC transporters 1.2.2. Phosphotransferase systems 1.2.3. ECF transporter 1.2.4. Transporters/ other
Related categories	transport proteins
Overview on the categories (Excel file) All genes and their categories (Excel file)

Importers

Uptake of carbon sources

• YurJ-(FrlM-FrlN)-FrlO: uptake of aminosugars
• AraN, AraP, AraQ: uptake of α-1,5-arabinooligosaccharides
• CycB, GanP, GanQ: uptake of galactotriose
• MdxE, MdxF, MdxG: uptake of maltodextrin
• AmyC, AmyD, MsmE: uptake of melibiose (probably)
• RbsA, RbsB, RbsC, RbsD: uptake of ribose
• RhiL-RhiF-RhiG: uptake of rhamnose oligosaccharides
• YtcP-YtcQ-YteP: uptake of polygalacturonan and rhamnogalacturonan

ATPase subunit of multiple sugar transport systems

• MsmX

Uptake of amino acids

• ArtP, ArtQ, ArtR: uptake of arginine
• TcyJ, TcyK, TcyL, TcyM, TcyN: uptake of cystine
• TcyA, TcyB, TcyC: uptake of cystine
• YxeM-YxeN-YxeO: uptake of S-(2-succino)cysteine (putative)
• GlnH, GlnM, GlnP, GlnQ: uptake of glutamine
• MetN, MetP, MetQ: uptake of methionine

Uptake of nucleosides

• NupO-NupP-NupQ: uptake of guanosine

Uptake of peptides

• AppA, AppB, AppC, AppD, AppF: uptake of oligopeptides
• DppB, DppC, DppD, DppE, YkfD: uptake of dipeptides
• OppA, OppB, OppC, OppD, OppF: uptake of oligopeptides

Uptake of compatible solutes for osmoprotection

• OpuAA-OpuAB-OpuAC: ABC transporter for glycine betaine
• OpuBA-OpuBB-OpuBC-OpuBD: ABC transporter for choline
• OpuCA-OpuCB-OpuCC-OpuCD: ABC transporter for glycine betaine/ carnitine/ choline

Uptake of cofactors

• YvrA-YvrB-YvrC: uptake of cobalamin

Uptake of iron/ siderophores

• YusV-FeuB-FeuC-FeuA: uptake of the siderophores enterobactin and bacillibactin
• FhuC-FhuB-FhuG-FhuD-YxeB: uptake of ferrichrome und ferrioxamine
• YclN-YclO-YclP-YclQ: uptake of petrobactin (a siderophore produced by B. anthracis and B. cereus)
• YusV-YfiZ-YfhA-YfiY: uptake of the siderophores schizokinen and arthrobactin
• YfmF-YfmD-YfmE-YfmC-YhfQ: uptake of iron/citrate

Uptake of ions

• MntB-MntA-MntC-MntD: uptake of manganese
• PstBA-PstBB-PstS-PstC-PstA: uptake of phosphate
• SsuA-SsuB-SsuC: uptake of aliphatic sulfonate
• ZnuA-ZnuB-ZnuC: uptake of zinc
• YvgM-YvgL: uptake of molybdenum (probably)

ABC transporters of unknown function

• LplA-LplB-LplC
• YckA-YckB
• YhcJ
• YhjP
• YjkB-YjkA
• YlmA
• YtlC-YtlD-YtlA
• (YtrB-YtrE)-(YtrC-YtrD)-YtrF

Exporters

Efflux of antibiotics

• VmlR: efflux of virginiamycin M and lincomycin
• BmrA: efflux of multiple antibiotics
• BmrC-BmrD: efflux of multiple antibiotics
• YfiL-YfiM-YfiN: probably efflux of linearmcin

Export of antibiotic substances

• AlbC-AlbD
• SunT

Export of peptides

• SkfE-SkfF: export of the spore killing factor
• YknY-YknZ
• BceA-BceB: export of bacitracin, plectasin, mersacidin and actagardine
• YxdL-YxdM
• PsdA-PsdB: export of lipid II-binding lantibiotics, such as nisin and gallidermin
• YxlF-YxlG
• YydI-YydJ: export of the modified YydF epipeptide, control of LiaR-LiaS activity

Export of cell wall components

• TagG-TagH: export of teichoic acid

Export of ions

• NatA-NatB: export of Na(+)

Exporters of unknown function

• YcbN
• YclH-YclI
• YdbJ-YdbK
• YdiF
• YfiB-YfiC

• YfmM
• YfmR
• YgaD
• YhaQ-YhaP
• YhcG-YhcE
• YhcH-YhcI
• YknU-YknV
• YkpA
• YthP-YthQ
• YvfR-YvfS
• YvrO-YvrN
• YwjA
• YybJ-(YybK-YybL)

Regulatory ABC transporters

• CydC-CydD: required for expression of cytochrome bd
• EcsA-EcsB: regulation of the secretion apparatus and of intra-membrane proteolysis
• FtsE-FtsX: activation of Spo0A and initiation of sporulation
• BmrC-BmrD: involved in the signalling pathway to activate KinA at the onset of sporulation
• SufC: required for the synthesis of Fe-S clusters

Relevant publications

Christoph Thomas, Robert Tampé
Structural and Mechanistic Principles of ABC Transporters.
Annu Rev Biochem: 2020, 89;605-636
[PubMed:32569521] [WorldCat.org] [DOI] (I p)

Kaspar P Locher
Mechanistic diversity in ATP-binding cassette (ABC) transporters.
Nat Struct Mol Biol: 2016, 23(6);487-93
[PubMed:27273632] [WorldCat.org] [DOI] (I p)

Susanne Gebhard
ABC transporters of antimicrobial peptides in Firmicutes bacteria - phylogeny, function and regulation.
Mol Microbiol: 2012, 86(6);1295-317
[PubMed:23106164] [WorldCat.org] [DOI] (I p)

Sebastian Dintner, Anna Staron, Evi Berchtold, Tobias Petri, Thorsten Mascher, Susanne Gebhard
Coevolution of ABC transporters and two-component regulatory systems as resistance modules against antimicrobial peptides in Firmicutes Bacteria.
J Bacteriol: 2011, 193(15);3851-62
[PubMed:21665979] [WorldCat.org] [DOI] (I p)

Thomas Eitinger, Dmitry A Rodionov, Mathias Grote, Erwin Schneider
Canonical and ECF-type ATP-binding cassette importers in prokaryotes: diversity in modular organization and cellular functions.
FEMS Microbiol Rev: 2011, 35(1);3-67
[PubMed:20497229] [WorldCat.org] [DOI] (I p)

Amy L Davidson, Elie Dassa, Cedric Orelle, Jue Chen
Structure, function, and evolution of bacterial ATP-binding cassette systems.
Microbiol Mol Biol Rev: 2008, 72(2);317-64, table of contents
[PubMed:18535149] [WorldCat.org] [DOI] (I p)

Y Quentin, G Fichant, F Denizot
Inventory, assembly and analysis of Bacillus subtilis ABC transport systems.
J Mol Biol: 1999, 287(3);467-84
[PubMed:10092453] [WorldCat.org] [DOI] (P p)

C F Higgins
ABC transporters: from microorganisms to man.
Annu Rev Cell Biol: 1992, 8;67-113
[PubMed:1282354] [WorldCat.org] [DOI] (P p)