Difference between revisions of "ABC transporters"

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* 1.2.1. [[ABC transporters]]
 
* 1.2.1. [[ABC transporters]]
 
* 1.2.2. [[Phosphotransferase systems]]
 
* 1.2.2. [[Phosphotransferase systems]]
−
* 1.2.3. [[Transporters/ other]]
+
* 1.2.3. [[ECF transporter]]
 +
* 1.2.4. [[Transporters/ other]]
 
|Related=
 
|Related=
 
[[transport proteins]]
 
[[transport proteins]]
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==Uptake of carbon sources==
 
==Uptake of carbon sources==
 
* [[YurJ]]-([[FrlM]]-[[FrlN]])-[[FrlO]]: uptake of aminosugars
 
* [[YurJ]]-([[FrlM]]-[[FrlN]])-[[FrlO]]: uptake of aminosugars
−
* [[AraN]], [[AraP]], [[AraQ]]: uptake of arabinose
+
* [[AraN]], [[AraP]], [[AraQ]]: uptake of α-1,5-arabinooligosaccharides
−
* [[CycB]], [[YvfL]], [[YvfM]]: uptake of cyclodextrin/maltodextrin (probably)
+
* [[CycB]], [[GanP]], [[GanQ]]: uptake of galactotriose
 
* [[MdxE]], [[MdxF]], [[MdxG]]: uptake of maltodextrin
 
* [[MdxE]], [[MdxF]], [[MdxG]]: uptake of maltodextrin
 
* [[AmyC]], [[AmyD]], [[MsmE]]: uptake of melibiose (probably)
 
* [[AmyC]], [[AmyD]], [[MsmE]]: uptake of melibiose (probably)
 
* [[RbsA]], [[RbsB]], [[RbsC]], [[RbsD]]: uptake of ribose
 
* [[RbsA]], [[RbsB]], [[RbsC]], [[RbsD]]: uptake of ribose
−
* ([[YtrB]]-[[YtrE]])-([[YtrC]]-[[YtrD]])-[[YtrF]]: uptake of acetoin
+
* [[RhiL]]-[[RhiF]]-[[RhiG]]: uptake of rhamnose oligosaccharides
 +
* [[YtcP]]-[[YtcQ]]-[[YteP]]: uptake of polygalacturonan and rhamnogalacturonan
  
 
===ATPase subunit of multiple sugar transport systems===
 
===ATPase subunit of multiple sugar transport systems===
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* [[TcyJ]], [[TcyK]], [[TcyL]], [[TcyM]], [[TcyN]]: uptake of cystine
 
* [[TcyJ]], [[TcyK]], [[TcyL]], [[TcyM]], [[TcyN]]: uptake of cystine
 
* [[TcyA]], [[TcyB]], [[TcyC]]: uptake of cystine
 
* [[TcyA]], [[TcyB]], [[TcyC]]: uptake of cystine
 +
* [[YxeM]]-[[YxeN]]-[[YxeO]]: uptake of S-(2-succino)cysteine (putative)
 
* [[GlnH]], [[GlnM]], [[GlnP]], [[GlnQ]]: uptake of glutamine
 
* [[GlnH]], [[GlnM]], [[GlnP]], [[GlnQ]]: uptake of glutamine
 
* [[MetN]], [[MetP]], [[MetQ]]: uptake of methionine
 
* [[MetN]], [[MetP]], [[MetQ]]: uptake of methionine
 +
 +
==Uptake of nucleosides==
 +
* [[NupO]]-[[NupP]]-[[NupQ]]: uptake of guanosine
  
 
==Uptake of peptides==
 
==Uptake of peptides==
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* [[OpuCA]]-[[OpuCB]]-[[OpuCC]]-[[OpuCD]]: [[ABC transporter]] for glycine betaine/ carnitine/ choline
 
* [[OpuCA]]-[[OpuCB]]-[[OpuCC]]-[[OpuCD]]: [[ABC transporter]] for glycine betaine/ carnitine/ choline
  
−
==Uptake of iron/ siderophores==
+
==Uptake of cofactors==
 +
* [[YvrA]]-[[YvrB]]-[[YvrC]]: uptake of cobalamin
 +
 
 +
==[[Iron metabolism|Uptake of iron/ siderophores]]==
 
* [[YusV]]-[[FeuB]]-[[FeuC]]-[[FeuA]]: uptake of the siderophores enterobactin and bacillibactin  
 
* [[YusV]]-[[FeuB]]-[[FeuC]]-[[FeuA]]: uptake of the siderophores enterobactin and bacillibactin  
 
* [[FhuC]]-[[FhuB]]-[[FhuG]]-[[FhuD]]-[[YxeB]]: uptake of ferrichrome und ferrioxamine
 
* [[FhuC]]-[[FhuB]]-[[FhuG]]-[[FhuD]]-[[YxeB]]: uptake of ferrichrome und ferrioxamine
−
* [[YclN]]-[[YclO]]-[[YclP]]-[[YclQ]]: uptake of petrobactin
+
* [[YclN]]-[[YclO]]-[[YclP]]-[[YclQ]]: uptake of petrobactin (a siderophore produced by ''B. anthracis'' and ''B. cereus'')
 
* [[YusV]]-[[YfiZ]]-[[YfhA]]-[[YfiY]]: uptake of the siderophores schizokinen and arthrobactin  
 
* [[YusV]]-[[YfiZ]]-[[YfhA]]-[[YfiY]]: uptake of the siderophores schizokinen and arthrobactin  
 
* [[YfmF]]-[[YfmD]]-[[YfmE]]-[[YfmC]]-[[YhfQ]]: uptake of iron/citrate
 
* [[YfmF]]-[[YfmD]]-[[YfmE]]-[[YfmC]]-[[YhfQ]]: uptake of iron/citrate
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* [[PstBA]]-[[PstBB]]-[[PstS]]-[[PstC]]-[[PstA]]: uptake of phosphate
 
* [[PstBA]]-[[PstBB]]-[[PstS]]-[[PstC]]-[[PstA]]: uptake of phosphate
 
* [[SsuA]]-[[SsuB]]-[[SsuC]]: uptake of aliphatic sulfonate
 
* [[SsuA]]-[[SsuB]]-[[SsuC]]: uptake of aliphatic sulfonate
−
* [[YcdI]]-[[YceA]]-[[YcdH]]: uptake of zinc
+
* [[ZnuA]]-[[ZnuB]]-[[ZnuC]]: uptake of zinc
 
* [[YvgM]]-[[YvgL]]: uptake of molybdenum (probably)
 
* [[YvgM]]-[[YvgL]]: uptake of molybdenum (probably)
−
 
−
==Uptake of cofactors==
 
−
* [[ThiW]]-([[ThiV]]-[[ThiX]])-[[ThiU]]: uptake of thiamine
 
  
 
==ABC transporters of unknown function==
 
==ABC transporters of unknown function==
 
* [[LplA]]-[[LplB]]-[[LplC]]
 
* [[LplA]]-[[LplB]]-[[LplC]]
 
* [[YckA]]-[[YckB]]
 
* [[YckA]]-[[YckB]]
−
* [[YesO]]-[[YesP]]-[[YesQ]]
+
* [[YhcJ]]
 
* [[YhjP]]
 
* [[YhjP]]
 
* [[YjkB]]-[[YjkA]]
 
* [[YjkB]]-[[YjkA]]
 
* [[YlmA]]
 
* [[YlmA]]
−
* [[YtcP]]-[[YtcQ]]-[[YteP]]
 
 
* [[YtlC]]-[[YtlD]]-[[YtlA]]
 
* [[YtlC]]-[[YtlD]]-[[YtlA]]
−
* [[YufO]]-[[YufP]]-[[YufQ]]
+
* ([[YtrB]]-[[YtrE]])-([[YtrC]]-[[YtrD]])-[[YtrF]]
−
* [[YvrA]]-[[YvrB]]-[[YvrC]]
 
−
* [[YxeM]]-[[YxeN]]-[[YxeO]]
 
  
 
=Exporters=
 
=Exporters=
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* [[VmlR]]: efflux of virginiamycin M and lincomycin
 
* [[VmlR]]: efflux of virginiamycin M and lincomycin
 
* [[BmrA]]: efflux of multiple antibiotics
 
* [[BmrA]]: efflux of multiple antibiotics
−
* [[YheH]]-[[YheI]]: efflux of multiple antibiotics
+
* [[BmrC]]-[[BmrD]]: efflux of multiple antibiotics
 +
* [[YfiL]]-[[YfiM]]-[[YfiN]]: probably efflux of linearmcin
  
 
==Export of antibiotic substances==
 
==Export of antibiotic substances==
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* [[SunT]]
 
* [[SunT]]
  
−
==Export of toxic peptides==
+
==Export of peptides==
−
* [[SkfE]]-[[SkfF]]
+
* [[SkfE]]-[[SkfF]]: export of the [[skfA|spore killing factor]]
 
* [[YknY]]-[[YknZ]]
 
* [[YknY]]-[[YknZ]]
 
* [[BceA]]-[[BceB]]: export of bacitracin, plectasin, mersacidin and actagardine
 
* [[BceA]]-[[BceB]]: export of bacitracin, plectasin, mersacidin and actagardine
 
* [[YxdL]]-[[YxdM]]
 
* [[YxdL]]-[[YxdM]]
 
* [[PsdA]]-[[PsdB]]: export of lipid II-binding lantibiotics, such as nisin and gallidermin
 
* [[PsdA]]-[[PsdB]]: export of lipid II-binding lantibiotics, such as nisin and gallidermin
 +
* [[YxlF]]-[[YxlG]]
 +
* [[YydI]]-[[YydJ]]: export of the modified [[YydF]] epipeptide, control of [[LiaR]]-[[LiaS]] activity
  
 
==Export of cell wall components==
 
==Export of cell wall components==
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==Exporters of unknown function==
 
==Exporters of unknown function==
−
* ([[YbxA]]-[[YbaE]])-[[YbaF]]
 
 
* [[YcbN]]
 
* [[YcbN]]
 
* [[YclH]]-[[YclI]]
 
* [[YclH]]-[[YclI]]
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* [[YdiF]]
 
* [[YdiF]]
 
* [[YfiB]]-[[YfiC]]
 
* [[YfiB]]-[[YfiC]]
−
* [[YfiL]]-[[YfiM]]-[[YfiN]]
+
 
 
* [[YfmM]]
 
* [[YfmM]]
 
* [[YfmR]]
 
* [[YfmR]]
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* [[YvrO]]-[[YvrN]]
 
* [[YvrO]]-[[YvrN]]
 
* [[YwjA]]
 
* [[YwjA]]
−
* [[YxlF]]-[[YxlG]]
 
 
* [[YybJ]]-([[YybK]]-[[YybL]])
 
* [[YybJ]]-([[YybK]]-[[YybL]])
  
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* [[EcsA]]-[[EcsB]]: regulation of the secretion apparatus and of intra-membrane proteolysis
 
* [[EcsA]]-[[EcsB]]: regulation of the secretion apparatus and of intra-membrane proteolysis
 
* [[FtsE]]-[[FtsX]]: activation of [[Spo0A]] and initiation of sporulation  
 
* [[FtsE]]-[[FtsX]]: activation of [[Spo0A]] and initiation of sporulation  
−
* [[YheH]]-[[YheI]]: involved in the signalling pathway to activate [[KinA]] at the onset of sporulation  
+
* [[BmrC]]-[[BmrD]]: involved in the signalling pathway to activate [[KinA]] at the onset of sporulation  
−
* [[SufC]]: required for the synthesis of Fe-S clusters  
+
* [[SufC]]: required for the [[Iron metabolism|synthesis of Fe-S clusters]]  
−
* [[YydI]]-([[YydJ]]-[[YydH]]): control of [[LiaR]]-[[LiaS]] activity
 
  
 
=Relevant publications=
 
=Relevant publications=
−
<pubmed> 10092453 1282354 18535149 20497229 </pubmed>
+
<pubmed> 10092453 1282354 18535149 20497229 21665979 23106164 27273632 ,32569521</pubmed>
 +
 
 
=Back to [[categories]]=
 
=Back to [[categories]]=

Latest revision as of 08:34, 25 June 2020

Parent categories
Neighbouring categories
Related categories

transport proteins


Importers

Uptake of carbon sources

ATPase subunit of multiple sugar transport systems

Uptake of amino acids

Uptake of nucleosides

Uptake of peptides

Uptake of compatible solutes for osmoprotection

Uptake of cofactors

Uptake of iron/ siderophores

Uptake of ions

ABC transporters of unknown function

Exporters

Efflux of antibiotics

  • VmlR: efflux of virginiamycin M and lincomycin
  • BmrA: efflux of multiple antibiotics
  • BmrC-BmrD: efflux of multiple antibiotics
  • YfiL-YfiM-YfiN: probably efflux of linearmcin

Export of antibiotic substances

Export of peptides

Export of cell wall components

Export of ions

Exporters of unknown function

Regulatory ABC transporters

Relevant publications

Christoph Thomas, Robert Tampé
Structural and Mechanistic Principles of ABC Transporters.
Annu Rev Biochem: 2020, 89;605-636
[PubMed:32569521] [WorldCat.org] [DOI] (I p)

Kaspar P Locher
Mechanistic diversity in ATP-binding cassette (ABC) transporters.
Nat Struct Mol Biol: 2016, 23(6);487-93
[PubMed:27273632] [WorldCat.org] [DOI] (I p)

Susanne Gebhard
ABC transporters of antimicrobial peptides in Firmicutes bacteria - phylogeny, function and regulation.
Mol Microbiol: 2012, 86(6);1295-317
[PubMed:23106164] [WorldCat.org] [DOI] (I p)

Sebastian Dintner, Anna Staron, Evi Berchtold, Tobias Petri, Thorsten Mascher, Susanne Gebhard
Coevolution of ABC transporters and two-component regulatory systems as resistance modules against antimicrobial peptides in Firmicutes Bacteria.
J Bacteriol: 2011, 193(15);3851-62
[PubMed:21665979] [WorldCat.org] [DOI] (I p)

Thomas Eitinger, Dmitry A Rodionov, Mathias Grote, Erwin Schneider
Canonical and ECF-type ATP-binding cassette importers in prokaryotes: diversity in modular organization and cellular functions.
FEMS Microbiol Rev: 2011, 35(1);3-67
[PubMed:20497229] [WorldCat.org] [DOI] (I p)

Amy L Davidson, Elie Dassa, Cedric Orelle, Jue Chen
Structure, function, and evolution of bacterial ATP-binding cassette systems.
Microbiol Mol Biol Rev: 2008, 72(2);317-64, table of contents
[PubMed:18535149] [WorldCat.org] [DOI] (I p)

Y Quentin, G Fichant, F Denizot
Inventory, assembly and analysis of Bacillus subtilis ABC transport systems.
J Mol Biol: 1999, 287(3);467-84
[PubMed:10092453] [WorldCat.org] [DOI] (P p)

C F Higgins
ABC transporters: from microorganisms to man.
Annu Rev Cell Biol: 1992, 8;67-113
[PubMed:1282354] [WorldCat.org] [DOI] (P p)


Back to categories

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