AccD

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  • Description: acetyl-CoA carboxylase (beta subunit)

Gene name accD
Synonyms yttI
Essential yes PubMed
Product acetyl-CoA carboxylase (beta subunit))
Function production of malonyl-CoA, the substrate for fatty acid biosynthesis
Gene expression levels in SubtiExpress: accD
Interactions involving this protein in SubtInteract: AccD
Metabolic function and regulation of this protein in SubtiPathways:
accD
MW, pI 32 kDa, 5.344
Gene length, protein length 873 bp, 290 aa
Immediate neighbours accA, ytsJ
Sequences Protein DNA DNA_with_flanks
Genetic context
AccD context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
AccD expression.png















Categories containing this gene/protein

biosynthesis of lipids, essential genes, phosphoproteins

This gene is a member of the following regulons

Spo0A regulon

The gene

Basic information

  • Locus tag: BSU29210

Phenotypes of a mutant

essential PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
    • phosphorylated on Arg-205 PubMed
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 2F9I (from Staphylococcus aureus; equivalent to AccD-AccA, 64% identity) PubMed
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Sigma factor:
  • Regulation:
    • expressed under conditions that trigger sporulation (Spo0A) PubMed
  • Regulatory mechanism:
  • Additional information:
    • number of protein molecules per cell (minimal medium with glucose and ammonium): 1119 PubMed
    • number of protein molecules per cell (complex medium with amino acids, without glucose): 1271 PubMed

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Stephen W White, Jie Zheng, Yong-Mei Zhang, Rock
The structural biology of type II fatty acid biosynthesis.
Annu Rev Biochem: 2005, 74;791-831
[PubMed:15952903] [WorldCat.org] [DOI] (P p)

John E Cronan, Grover L Waldrop
Multi-subunit acetyl-CoA carboxylases.
Prog Lipid Res: 2002, 41(5);407-35
[PubMed:12121720] [WorldCat.org] [DOI] (P p)


Original Publications