MntR

• Description: transcriptional regulator, (repression of mntH and mntA-mntB-mntC-mntD under high Mn(II) conditions)

Gene name	mntR
Synonyms	yqhN
Essential	no
Product	transcriptional regulator (DtxR family)
Function	regulation of manganese transport
Gene expression levels in SubtiExpress: mntR
Metabolic function and regulation of this protein in SubtiPathways: mntR
MW, pI	16 kDa, 5.631
Gene length, protein length	426 bp, 142 aa
Immediate neighbours	yqhO, lipM
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

trace metal homeostasis (Cu, Zn, Ni, Mn, Mo), transcription factors and their control, membrane proteins

The MntR regulon:

• mntA-mntB-mntC-mntD, mntH

The gene

Basic information

• Locus tag: BSU24520

Database entries

• BsubCyc: BSU24520

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s): Mn(2+) acts as co-repressor (according to PubMed)

• Effectors of protein activity:

• Interactions:
  • active as dimer (according to PubMed)

• Localization: cell membrane (according to Swiss-Prot)

Database entries

• BsubCyc: BSU24520

• Structure: 2F5D (complex with manganese), 2HYG (apo-form)

• UniProt: P54512

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Expression browser: mntR PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:
  • number of protein molecules per cell (minimal medium with glucose and ammonium): 376 PubMed
  • number of protein molecules per cell (complex medium with amino acids, without glucose): 790 PubMed
  • number of protein molecules per cell (minimal medium with glucose and ammonium, exponential phase): 900 PubMed
  • number of protein molecules per cell (minimal medium with glucose and ammonium, early stationary phase after glucose exhaustion): 300 PubMed
  • number of protein molecules per cell (minimal medium with glucose and ammonium, late stationary phase after glucose exhaustion): 488 PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

John Helmann, Cornell University, USA Homepage

Richard Brennan, Houston, Texas, USA Homepage