mntH

mntH
168

manganese transporter (proton symport)

Locus
BSU_04360
Molecular weight
45.52 kDa
Isoelectric point
9.89
Protein length
425 aaSequenceBlast
Gene length
1278 bpSequenceBlast
Function
manganese uptake
Product
manganese transporter (proton symport))
Essential
no
Synonyms
mntH, ydaR
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1914 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
491,147  492,424
Phenotypes of a mutant
suppresses the Mn2+ sensitivity of a mntR mutant PubMed
The protein
Catalyzed reaction/ biological activity
uptake of Mn2+
Protein family
NRAMP family (with YcsG, according to UniProt)
Structure
4WGV (PDB) (from Staphylococcus capitis, 40% identity) PubMed
P96593 (AlphaFold)
Localization
cell membrane (according to UniProt)
Expression and Regulation
Operons
Genes
mntH
Description
PubMed
Regulation
repressed at high Mn(II) concentrations (MntR) PubMed
Regulatory mechanism
MntR: repression, PubMed, in mntR regulon
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mntH

2025-03-23 04:52:45

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885b4248cfbb7c521c5ee4362481181da1222022

077FE4B0E11A75442C6D47908B77E2FEE9255DA7

Biological materials
Mutant
MGNA-C116 (ydaR::erm), available at the NBRP B. subtilis, Japan
JH642 and its derivatives: natural deletion of the 18 kb ydzA-mntH region encompassing the genes ydzA-topB-ydaJ-ydaK-ydaL-ydaM-ydaN-kimA-mutT-ydaP-ydzK-mntH PubMed
BKE04360 (mntH::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATGTCTCACCTGAATTCTG,  downstream forward: _UP4_TAAAAAAACCGGCTTCTAAA
BKK04360 (mntH::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATGTCTCACCTGAATTCTG,  downstream forward: _UP4_TAAAAAAACCGGCTTCTAAA
Labs working on this gene/protein
John Helmann, Cornell University, USA Homepage
References
Reviews
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Original Publications
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Time of last update: 2025-03-31 16:50:42

Author of last update: Jstuelk