SpoVT

• Description: transcription activator and repressor of SigG-dependent genes
  
  

Gene name	spoVT
Synonyms	yabL
Essential	no
Product	transcriptional regulator
Function	regulation of forespore gene expression
Gene expression levels in SubtiExpress: spoVT
Metabolic function and regulation of this protein in SubtiPathways: spoVT
MW, pI	19 kDa, 4.676
Gene length, protein length	534 bp, 178 aa
Immediate neighbours	mfd, yabM
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

transcription factors and their control, sporulation proteins

This gene is a member of the following regulons

SigF regulon, SigG regulon

The gene

Basic information

• Locus tag: BSU00560

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s): AbrB, Abh (only the N-terminal domains (aa 1 through 50) are conserved between SpoVT and the two paralogues)

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: Cytoplasm (Homogeneous) PubMed

Database entries

• Structure: 2W1R (full-length), 2W1T (C-terminal domain) 2RO5 (recognition domain)

• UniProt: P37554

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: spoVT PubMed

• Expression browser: spoVT PubMed

• Sigma factor: SigF PubMed, SigG PubMed

• Regulation: expressed in the forespore (SigG) PubMed

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Arturo Ramirez-Peralta, Kerry-Ann V Stewart, Stacy K Thomas, Barbara Setlow, Zhan Chen, Yong-qing Li, Peter Setlow
Effects of the SpoVT regulatory protein on the germination and germination protein levels of spores of Bacillus subtilis.
J Bacteriol: 2012, 194(13);3417-25
[PubMed:22522895] [WorldCat.org] [DOI] (I p)

Iris Asen, Sergej Djuranovic, Andrei N Lupas, Kornelius Zeth
Crystal structure of SpoVT, the final modulator of gene expression during spore development in Bacillus subtilis.
J Mol Biol: 2009, 386(4);962-75
[PubMed:18996130] [WorldCat.org] [DOI] (I p)

Stephanie T Wang, Barbara Setlow, Erin M Conlon, Jessica L Lyon, Daisuke Imamura, Tsutomu Sato, Peter Setlow, Richard Losick, Patrick Eichenberger
The forespore line of gene expression in Bacillus subtilis.
J Mol Biol: 2006, 358(1);16-37
[PubMed:16497325] [WorldCat.org] [DOI] (P p)

Jean-Christophe Meile, Ling Juan Wu, S Dusko Ehrlich, Jeff Errington, Philippe Noirot
Systematic localisation of proteins fused to the green fluorescent protein in Bacillus subtilis: identification of new proteins at the DNA replication factory.
Proteomics: 2006, 6(7);2135-46
[PubMed:16479537] [WorldCat.org] [DOI] (P p)

Fude Yao, Mark A Strauch
Independent and interchangeable multimerization domains of the AbrB, Abh, and SpoVT global regulatory proteins.
J Bacteriol: 2005, 187(18);6354-62
[PubMed:16159768] [WorldCat.org] [DOI] (P p)

Tran Cat Dong, Simon M Cutting, Richard J Lewis
DNA-binding studies on the Bacillus subtilis transcriptional regulator and AbrB homologue, SpoVT.
FEMS Microbiol Lett: 2004, 233(2);247-56
[PubMed:15063493] [WorldCat.org] [DOI] (P p)

I Bagyan, J Hobot, S Cutting
A compartmentalized regulator of developmental gene expression in Bacillus subtilis.
J Bacteriol: 1996, 178(15);4500-7
[PubMed:8755877] [WorldCat.org] [DOI] (P p)