sigG

sigG
168

RNA polymerase sporulation forespore-specific (late) sigma factor SigG

Locus
BSU_15330
Molecular weight
29.92 kDa
Isoelectric point
5.5
Protein length
260 aaSequenceBlast
Gene length
783 bpSequenceBlast
Function
transcription of sporulation genes (late forespore)
Product
RNA polymerase sporulation forespore-specific (late) sigma factor SigG
Essential
no
Synonyms
sigG, spoIIIG
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG5813 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,605,630  1,606,412
The protein
Protein family
Sigma-70 factor family (according to UniProt)
Structure
1L0O (PDB) (SigF in complex with SpoIIAB, Geobacillus stearothermophilus, 47% identity) PubMed
P19940 (AlphaFold)
Effectors of protein activity
CsfB inhibits SigG activity PubMed
the activity of SigG-containing RNA polymerase is modulated by YlyA PubMed
Paralogous protein(s)
SigF
Expression and Regulation
Operons
Genes
spoIIGA-sigE-sigG
Description
PubMed
Regulation
''spoIIGA'': expressed under conditions that trigger sporulation (Spo0A) PubMed
Regulatory mechanism
SinR: repression, in sinR regulon
Spo0A: activation, PubMed, in spo0A regulon
AbrB: repression, PubMed, in abrB regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
SigG: sigma factor, PubMed, in sigG regulon
SigF: sigma factor, in sigF regulon
Additional information
the mRNA half-life is about 2.6 min PubMed
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spoIIGA→sigG

2025-03-16 16:21:35

ghost

141

3354b759a5d3c11fb5b0d40216c1a7e1d8249a30

020EF37B0706DBB0AF1DC411F77E0B6D94001319

Genes
sigG
Description
PubMed
Regulation
''spoIIGA'': expressed under conditions that trigger sporulation (Spo0A) PubMed
Additional information
the mRNA half-life is about 2.6 min PubMed
a conserved hairpin in the 5' leader sequence of the sigG mRNA occludes the ribosome-binding site, this reduces translation by up to 4-fold PubMed
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sigG

2025-03-22 23:25:59

Jstuelk

142

eba0bfafa2452d7bb4af940ab4e44f7cbc16dfc3

A3191BCF399586B987555C0E304550BD16906D4F

Biological materials
Mutant
BKE15330 (sigG::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CACTTTTTTCCCTCCCTACA,  downstream forward: _UP4_TAATGAAAAGCCTTTAAAAC
BKK15330 (sigG::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CACTTTTTTCCCTCCCTACA,  downstream forward: _UP4_TAATGAAAAGCCTTTAAAAC
Labs working on this gene/protein
Charles Moran, Emory University, NC, USA homepage
References
Reviews
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Original Publications
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The SigG regulon
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5F24258282F3166B7696B9E9ABC1706E4D06C944

Page visits: 8559

Time of last update: 2025-03-31 15:26:13

Author of last update: Jstuelk