abrB

abrB
168

transcriptional regulator of transition state genes

Locus
BSU_00370
Molecular weight
10.63 kDa
Isoelectric point
6.57
Protein length
96 aaSequenceBlast
Gene length
291 bpSequenceBlast
Function
regulation of gene expression during the transition from growth to stationary phase
Product
transcriptional regulator
Essential
no
Synonyms
abrB, cpsX, tolB
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG2002 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
44,848 → 45,138
Phenotypes of a mutant
No swarming motility on B medium PubMed
The protein
Domains
SpoVT-AbrB domain (aa 7-52) (according to UniProt)
Structure
2MJG (PDB) (full-length protein) PubMed
1Z0R (PDB) (N-terminal DNA recognition domain) PubMed
P08874 (AlphaFold)
Modification
phosphorylated on Ser-86 PubMed by PrkC, PrkD, and YabT results in loss of DNA-binding activity PubMed
Effectors of protein activity
interaction with AbbA results in inactivation of AbrB PubMed
Paralogous protein(s)
SpoVT, Abh
Expression and Regulation
Operons
Genes
abrB
Description
PubMed
Regulation
expressed at the onset of stationary phase PubMed
Regulatory mechanism
Spo0A: repression, -P PubMed, in spo0A regulon
AbrB: repression, PubMed, in abrB regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
Additional information
degradation of the ''abrB'' mRNA is triggered by base-pairing with RnaC PubMed
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abrB

2025-03-31 17:59:14

ghost

125

65f112afac8637a86c400c198f88bcfd98eb2938

29CADBB12EED79873A2D269725A6A283680F56A3

Biological materials
Mutant
TT731 (aphA3)
1A935 (abrB::cat), PubMed, available at BGSC
GP1548 (abrB::ermC), available in Stülke lab
BKE00370 (ΔabrB::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTCTCCTCCCAAGAGATA,  downstream forward: _UP4_TAATCATTTCTTGTACAAAA
BKK00370 (ΔabrB::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTCTCCTCCCAAGAGATA,  downstream forward: _UP4_TAATCATTTCTTGTACAAAA
Two-hybrid system
B. pertussis adenylate cyclase-based bacterial two hybrid system (BACTH), available in Stülke lab
Labs working on this gene/protein
Richard Losick, Harvard Univ., Cambridge, USA homepage
Mark Strauch, Baltimore, USA homepage
References
Reviews
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Original Publications
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The AbrB regulon
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E5110D9C36E8C55AFD1419987B14A53232165F20

Page visits: 22750

Time of last update: 2025-04-01 15:19:02

Author of last update: Jstuelk