ThiG

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  • Description: hydroxyethylthiazole phosphate biosynthesis

Gene name thiG
Synonyms yjbT
Essential no
Product thiamin thiazole synthase
Function biosynthesis of thiamine
Gene expression levels in SubtiExpress: thiG
Interactions involving this protein in SubtInteract: ThiG
Metabolic function and regulation of this protein in SubtiPathways:
Thiamin
MW, pI 26 kDa, 4.718
Gene length, protein length 768 bp, 256 aa
Immediate neighbours thiS, thiF
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
ThiG context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
ThiG expression.png




























Categories containing this gene/protein

biosynthesis of cofactors, phosphoproteins

This gene is a member of the following regulons

Thi-box

The gene

Basic information

  • Locus tag: BSU11690

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: thiG family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification: phosphorylated on ser/ thr/ tyr PubMed, PubMed
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Sigma factor:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Christopher T Jurgenson, Tadhg P Begley, Steven E Ealick
The structural and biochemical foundations of thiamin biosynthesis.
Annu Rev Biochem: 2009, 78;569-603
[PubMed:19348578] [WorldCat.org] [DOI] (I p)

T P Begley, D M Downs, S E Ealick, F W McLafferty, A P Van Loon, S Taylor, N Campobasso, H J Chiu, C Kinsland, J J Reddick, J Xi
Thiamin biosynthesis in prokaryotes.
Arch Microbiol: 1999, 171(5);293-300
[PubMed:10382260] [WorldCat.org] [DOI] (P p)

Original publications