FabL

Gene name	fabL
Synonyms	yfhR, ygaA
Essential	no
Product	enoyl-acyl carrier protein reductase
Function	fatty acid biosynthesis
Gene expression levels in SubtiExpress: fabL
Metabolic function and regulation of this protein in SubtiPathways: Lipid synthesis
MW, pI	27 kDa, 5.967
Gene length, protein length	750 bp, 250 aa
Immediate neighbours	yfhS, sspE
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

biosynthesis of lipids, sporulation proteins

This gene is a member of the following regulons

SigG regulon, SpoVT regulon, YfhP regulon

The gene

Basic information

• Locus tag: BSU08650

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s): FabI, one of the two proteins has to be present for viability PubMed

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure: 3OIC PubMed

• UniProt: P71079

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon:
  • mutY-fabL-sspE PubMed
  • fabL-sspE PubMed

• Expression browser: fabL PubMed

• Sigma factor: SigA PubMed, SigG PubMed

• Regulation:
  • repressed by YfhP during exponential growth PubMed
  • repressed by SpoVT during forespore expression PubMed

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

Yasutaro Fujita, Hiroshi Matsuoka, Kazutake Hirooka
Regulation of fatty acid metabolism in bacteria.
Mol Microbiol: 2007, 66(4);829-39
[PubMed:17919287] [WorldCat.org] [DOI] (P p)

Stephen W White, Jie Zheng, Yong-Mei Zhang, Rock
The structural biology of type II fatty acid biosynthesis.
Annu Rev Biochem: 2005, 74;791-831
[PubMed:15952903] [WorldCat.org] [DOI] (P p)