PtpZ

• Description: phosphotyrosine protein phosphatase, antagonist to PtkA
  
  

Gene name	ptpZ
Synonyms	ywqE
Essential	no
Product	phosphotyrosine protein phosphatase, antagonist to PtkA
Function	protein tyrosine dephosphorylation
Interactions involving this protein in SubtInteract: PtpZ
MW, pI	28 kDa, 6.66
Gene length, protein length	762 bp, 254 aa
Immediate neighbours	ugd, ptkA
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

biofilm formation, protein modification

This gene is a member of the following regulons

AbrB regulon

The gene

Basic information

• Locus tag: BSU36240

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: Protein tyrosine phosphate + H₂O = protein tyrosine + phosphate (according to Swiss-Prot), dephosphorylation of Ugd, TuaD and PtkA PubMed

• Protein family: cpsB/capC family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure: 3QY7 PubMed

• UniProt: P96717

• KEGG entry: [2]

• E.C. number: 3.1.3.48

Expression and regulation

• Operon: tkmA-ptkA-ptpZ-ugd PubMed

• Expression browser: ptpZ PubMed

• Sigma factor: SigA PubMed

• Regulation:

• Regulatory mechanism:
  • DegU-P: transcription repression PubMed
  • AbrB: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Additional publications: PubMed