MntR

• Description: transcriptional regulator, (repression of mntH and mntA-mntB-mntC-mntD under high Mn(II) conditions)

Gene name	mntR
Synonyms	yqhN
Essential	no
Product	transcriptional regulator (DtxR family)
Function	regulation of manganese transport
Gene expression levels in SubtiExpress: mntR
Metabolic function and regulation of this protein in SubtiPathways: Stress
MW, pI	16 kDa, 5.631
Gene length, protein length	426 bp, 142 aa
Immediate neighbours	yqhO, lipM
Sequences	Protein DNA Advanced_DNA
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

trace metal homeostasis (Cu, Zn, Ni, Mn, Mo), transcription factors and their control, membrane proteins

The MntR regulon:

• mntA-mntB-mntC-mntD, mntH

The gene

Basic information

• Locus tag: BSU24520

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s): Mn(2+) acts as co-repressor (according to PubMed)

• Effectors of protein activity:

• Interactions:
  • active as dimer (according to PubMed)

• Localization: cell membrane (according to Swiss-Prot)

Database entries

• Structure: 2F5D (complex with manganese), 2HYG (apo-form)

• UniProt: P54512

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Expression browser: mntR PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

John Helmann, Cornell University, USA Homepage

Richard Brennan, Houston, Texas, USA Homepage

References

Reviews

Sabine Brantl, Andreas Licht
Characterisation of Bacillus subtilis transcriptional regulators involved in metabolic processes.
Curr Protein Pept Sci: 2010, 11(4);274-91
[PubMed:20408793] [WorldCat.org] [DOI] (I p)