Difference between revisions of "Spo0A"

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|style="background:#ABCDEF;" align="center"|'''Function''' || initiation of sporulation
 
|style="background:#ABCDEF;" align="center"|'''Function''' || initiation of sporulation
 
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/glutamate.html Ammonium/ glutamate], [http://subtiwiki.uni-goettingen.de/pathways/carbon_flow.html Central C-metabolism], [http://subtiwiki.uni-goettingen.de/pathways/carbohydrate_metabolic_pathways.html Sugar catabolism], [http://subtiwiki.uni-goettingen.de/pathways/stress_response.html Stress], [http://subtiwiki.uni-goettingen.de/pathways/tRNA_charging.html tRNA charging]'''
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/glutamate.html Ammonium/ glutamate], [http://subtiwiki.uni-goettingen.de/pathways/carbon_flow.html Central C-metabolism],<br/>[http://subtiwiki.uni-goettingen.de/pathways/carbohydrate_metabolic_pathways.html Sugar catabolism], [http://subtiwiki.uni-goettingen.de/pathways/stress_response.html Stress], [http://subtiwiki.uni-goettingen.de/pathways/tRNA_charging.html tRNA charging]'''
 
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|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 29 kDa, 5.989   
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 29 kDa, 5.989   
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__TOC__
 
__TOC__
  
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=The gene=
 
=The gene=

Revision as of 10:40, 17 June 2009

  • Description: two-component response regulator, initiation of sporulation

Gene name spo0A
Synonyms spo0C, spo0G, spoIIL, sof-1
Essential no
Product two-component response regulator
Function initiation of sporulation
Metabolic function and regulation of this protein in SubtiPathways:
Ammonium/ glutamate, Central C-metabolism,
Sugar catabolism, Stress, tRNA charging
MW, pI 29 kDa, 5.989
Gene length, protein length 801 bp, 267 aa
Immediate neighbours yqiG, spoIVB
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
Spo0A context.gif
This image was kindly provided by SubtiList






The gene

Basic information

  • Locus tag: BSU24220

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Genes controlled by Spo0A

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification: receives phosphorylation from Spo0B, dephosphorylation by Spo0E
  • Cofactor(s):
  • Effectors of protein activity:
  • Localization:

Database entries

  • Structure: 1QMP (with phosphorylated aspartate, Geobacillus stearothermophilus), 1FC3 (trans-activation domain, Geobacillus stearothermophilus), 1LQ1 (complex with DNA)
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Regulation:
    • repressed under conditions that trigger sporulation (Spo0A) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References