DhbC

• Description: isochorismate synthase
  
  

Gene name	dhbC
Synonyms
Essential	no
Product	isochorismate synthase
Function	biosynthesis of the siderophore bacillibactin
Gene expression levels in SubtiExpress: dhbC
Metabolic function and regulation of this protein in SubtiPathways: DhbC
MW, pI	43 kDa, 5.168
Gene length, protein length	1194 bp, 398 aa
Immediate neighbours	dhbE, dhbA
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

acquisition of iron, iron metabolism, phosphoproteins

This gene is a member of the following regulons

AbrB regulon, Fur regulon

The gene

Basic information

• Locus tag: BSU31990

Database entries

• BsubCyc: BSU31990

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: Chorismate = isochorismate (according to Swiss-Prot)

• Protein family: isochorismate synthase family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification: phosphorylation on Ser-271 PubMed

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• BsubCyc: BSU31990

• Structure: 3OS6, (from B. anthracis, 56% identity, 70% similarity)

• UniProt: P45744

• KEGG entry: [3]

• E.C. number: 5.4.4.2

Expression and regulation

• Operon: dhbA-dhbC-dhbE-dhbB-dhbF PubMed

• Expression browser: dhbC PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • induced by iron starvation (Fur) PubMed

• Regulatory mechanism:
  • Fur: transcription repression PubMed
  • AbrB: transcription repression PubMed

• Additional information:
  • the amount of the mRNA is substantially decreased upon depletion of RNase Y PubMed
  • number of protein molecules per cell (minimal medium with glucose and ammonium): 9037 PubMed
  • number of protein molecules per cell (complex medium with amino acids, without glucose): 3893 PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: