SpoIVB

• Description: serine protease, cleaves SpoIVFA, this results in pro-SigK processing/activation in the mother-cell, does also cleave CtpB
  
  

Gene name	spoIVB
Synonyms
Essential	no
Product	serine protease
Function	control of SigK activation
Gene expression levels in SubtiExpress: spoIVB
Interactions involving this protein in SubtInteract: SpoIVB
MW, pI	45 kDa, 8.842
Gene length, protein length	1275 bp, 425 aa
Immediate neighbours	spo0A, recN
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

sigma factors and their control, sporulation proteins

This gene is a member of the following regulons

SigF regulon, SigG regulon

The gene

Basic information

• Locus tag: BSU24230

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: Self-cleaves 52-Val-|-Asn-53, 62-Ala-|-Phe-63 and 74-Val-|-Thr-75 at the N-terminus of SpoIVB (according to Swiss-Prot)

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • SpoIVB-BofA PubMed
  • BofC-SpoIVB PubMed

• Localization: cytoplasm (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: P17896

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: spoIVB PubMed

• Expression browser: spoIVB PubMed

• Sigma factor: SigF PubMed, SigG PubMed

• Regulation:
  • expressed during sporulation in the forespore (SigF, SigG, SpoVT) PubMed

• Regulatory mechanism:
  • SpoVT: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

Simon Cutting, London, UK homepage