ctpB
168

carboxy-terminal processing serine protease, cleaves SpoIVFA, this results in processing of pro-SigK

Locus

BSU_35240

Molecular weight

52.63 kDa

Isoelectric point

8.64

Protein length

480 aaSequenceBlast

Gene length

1443 bpSequenceBlast

Function

control of SigK activation

Product

carboxy-terminal processing serine protease, cleaves SpoIVFA

Essential

Synonyms

ctpB, yvjB

Outlinks

BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Hide small RNAsZoom:

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0793 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene

Coordinates

3,622,356 3,623,798

The protein

Catalyzed reaction/ biological activity

The enzyme shows specific recognition of a C-terminal tripeptide, Xaa-Yaa-Zaa, in which Xaa is preferably Ala or Leu, Yaa is preferably Ala or Tyr, and Zaa is preferably Ala, but then cleaves at a variable distance from the C-terminus. A typical cleavage is -Ala-Ala-|-Arg-Ala-Ala-Lys-Glu-Asn-Tyr-Ala-Leu-Ala-Ala (according to UniProt)

Protein family

Peptidase s41a family (together with CtpA, according to Uniprot)

PDZ protease PubMed

Domains

signal peptide (aa 1 - 23) (according to Uniprot)

PDZ domain (aa 92 - 182) (according to Uniprot)

S41 peptidase domain (by similarity to CtpA) PubMed

peptidoglycan binding domain (C-terminal) (by similarity to CtpA) PubMed

Structure

4C2C (PDB) PubMed

forms a ring-like scaffold with two narrow tunnels for substrate binding PubMed

O35002 (AlphaFold)