Difference between revisions of "DnaE"
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* '''[[SubtInteract|Interactions]]:''' | * '''[[SubtInteract|Interactions]]:''' | ||
** part of the [[replisome]]: [[PolC]]-[[HolA]]-[[HolB]]-[[DnaX]]-[[DnaN]]-[[DnaG]]-[[DnaC]]-[[DnaI]]-[[DnaD]]-[[SsbA]]-[[DnaE]]-[[PriA]]-[[DnaB]] {{PubMed|20122408}} | ** part of the [[replisome]]: [[PolC]]-[[HolA]]-[[HolB]]-[[DnaX]]-[[DnaN]]-[[DnaG]]-[[DnaC]]-[[DnaI]]-[[DnaD]]-[[SsbA]]-[[DnaE]]-[[PriA]]-[[DnaB]] {{PubMed|20122408}} | ||
| + | ** [[DnaE]]-[[MutL]] {{PubMed|21958350}} | ||
| + | ** [[DnaE]]-[[MutS]] {{PubMed|21958350}} | ||
| + | ** [[DnaE]]-[[DnaN]] {{PubMed|21958350}} | ||
| + | ** [[DnaE]]-[[SsbA]] {{PubMed|21958350}} | ||
| − | * '''[[Localization]]:''' cytoplasm (according to Swiss-Prot) | + | * '''[[Localization]]:''' |
| + | ** forms foci, the foci dissappear after the formation of DNA mismatches in a [[MutS]]-dependent manner or after DNA replication arrest {{PubMed|21958350}} | ||
| + | ** cytoplasm (according to Swiss-Prot) | ||
=== Database entries === | === Database entries === | ||
| Line 133: | Line 139: | ||
=References= | =References= | ||
| − | + | '''Additional publications:''' {{PubMed|21958350}} | |
<pubmed>,11721055,14593098,16267290, 20122408 </pubmed> | <pubmed>,11721055,14593098,16267290, 20122408 </pubmed> | ||
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 12:07, 24 October 2011
- Description: DNA polymerase III (alpha subunit), part of the replisome
| Gene name | dnaE |
| Synonyms | |
| Essential | yes PubMed |
| Product | DNA polymerase III (alpha subunit) |
| Function | DNA replication |
| Interactions involving this protein in SubtInteract: DnaE | |
| MW, pI | 125 kDa, 6.02 |
| Gene length, protein length | 3345 bp, 1115 aa |
| Immediate neighbours | ytsJ, ytrH |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
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Contents
Categories containing this gene/protein
DNA replication, essential genes
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU29230
Phenotypes of a mutant
essential PubMed
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1) (according to Swiss-Prot)
- Protein family: DnaE subfamily (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
Database entries
- Structure:
- UniProt: O34623
- KEGG entry: [3]
- E.C. number: 2.7.7.7
Additional information
Expression and regulation
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Additional publications: PubMed
