Difference between revisions of "Biosynthesis of cofactors"
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* 2.6.6. [[Miscellaneous metabolic pathways]] | * 2.6.6. [[Miscellaneous metabolic pathways]] | ||
|Related= | |Related= | ||
| − | + | * [[BirA regulon]] | |
| + | * [[FMN-box]] | ||
| + | * [[NadR regulon]] | ||
| + | * [[Thi-box]] | ||
|}} | |}} | ||
| Line 27: | Line 30: | ||
=== Biosynthesis/ acquisition of riboflavin/ fad === | === Biosynthesis/ acquisition of riboflavin/ fad === | ||
| − | * [[ribA]] | + | * ''[[ribA]]'' |
| − | * [[ribC]] | + | * ''[[ribC]]'' |
| − | * [[ribD]] | + | * ''[[ribD]]'' |
| − | * [[ribE]] | + | * ''[[ribE]]'' |
| − | * [[ribH]] | + | * ''[[ribH]]'' |
| − | * [[ribT]] | + | * ''[[ribR]]'' |
| − | * [[ribU]] | + | * ''[[ribT]]'' |
| + | * ''[[ribU]]'' | ||
| + | * ''[[ycsE]]'' | ||
=== Biosynthesis/ acquisition of thiamine === | === Biosynthesis/ acquisition of thiamine === | ||
* [[dxs]] | * [[dxs]] | ||
| − | |||
* [[tenA]] | * [[tenA]] | ||
* [[tenI]] | * [[tenI]] | ||
| Line 56: | Line 60: | ||
* [[ylmB]] | * [[ylmB]] | ||
* [[yloS]] | * [[yloS]] | ||
| − | |||
| − | |||
| − | |||
=== Biosynthesis of coenzyme a === | === Biosynthesis of coenzyme a === | ||
| Line 103: | Line 104: | ||
* [[ylnF]] | * [[ylnF]] | ||
| − | === Biosynthesis of lipoic acid === | + | === Biosynthesis of lipoic acid (For complete biosynthetic pathway see {{PubMed|21338421}}) === |
* [[lipA]] | * [[lipA]] | ||
* [[lipM]] | * [[lipM]] | ||
| + | * [[lplJ]] | ||
| + | * [[lipL]] | ||
| + | * [[gcvH]] | ||
=== Biosynthesis of menaquinone === | === Biosynthesis of menaquinone === | ||
| Line 130: | Line 134: | ||
* [[moeA]] | * [[moeA]] | ||
* [[moeB]] | * [[moeB]] | ||
| + | * [[ydiG]] | ||
=== Biosynthesis of nad(p) === | === Biosynthesis of nad(p) === | ||
| − | * [[nadA]] | + | * ''[[nadA]]'' |
| − | * [[nadB]] | + | * ''[[nadB]]'' |
| − | * [[nadC]] | + | * ''[[nadC]]'' |
| − | * [[nadD]] | + | * ''[[nadD]]'' |
| − | * [[nadE]] | + | * ''[[nadE]]'' |
| − | * [[nadF]] | + | * ''[[nadF]]'' |
| − | * [[nadR]] | + | * ''[[nadR]]'' |
| − | * [[nifS]] | + | * ''[[niaP]]'' |
| − | * [[ytdI]] | + | * ''[[nifS]]'' |
| + | * ''[[ytdI]]'' | ||
=== Biosynthesis of pyridoxal phosphate === | === Biosynthesis of pyridoxal phosphate === | ||
| Line 146: | Line 152: | ||
* [[pdxS]] | * [[pdxS]] | ||
* [[pdxT]] | * [[pdxT]] | ||
| + | |||
| + | == Metabolism of cofactors in [http://subtiwiki.uni-goettingen.de/subtipathways.html ''Subti''Pathways]== | ||
| + | |||
| + | * [http://subtiwiki.uni-goettingen.de/pathways/CoA_synthesis.html CoA synthesis] | ||
| + | |||
| + | * [http://subtiwiki.uni-goettingen.de/pathways/folate_biosynthesis.html Folate biosynthesis] | ||
| + | |||
| + | * [http://subtiwiki.uni-goettingen.de/pathways/menaquinone.html Menaquinone] | ||
| + | |||
| + | * [http://subtiwiki.uni-goettingen.de/pathways/riboflavin.html Riboflavin and FAD synthesis] | ||
| + | |||
| + | * [http://subtiwiki.uni-goettingen.de/pathways/thiamin.html Thiamin synthesis] | ||
| + | |||
| + | * [http://subtiwiki.uni-goettingen.de/pathways/biotin/index.html Biotin synthesis] | ||
| + | |||
| + | ==Important original publications== | ||
| + | <pubmed> 24972371 28196402</pubmed> | ||
==Important reviews== | ==Important reviews== | ||
| − | <pubmed> 19348578 18314013 14675553 10382260 | + | <pubmed> 11153271 22616866 19348578 18314013 14675553 10382260 24442413 21646432,21437340 26758294 27074917 27890703</pubmed> |
| − | </pubmed> | + | |
| + | =Back to [[categories]]= | ||
Latest revision as of 16:58, 15 February 2017
| Parent categories | |
| Neighbouring categories |
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| Related categories | |
Contents
- 1 Genes in this functional category
- 1.1 Biosynthesis/ acquisition of biotin
- 1.2 Biosynthesis/ acquisition of riboflavin/ fad
- 1.3 Biosynthesis/ acquisition of thiamine
- 1.4 Biosynthesis of coenzyme a
- 1.5 Biosynthesis of folate
- 1.6 Biosynthesis of heme/ siroheme
- 1.7 Biosynthesis of lipoic acid (For complete biosynthetic pathway see PubMed)
- 1.8 Biosynthesis of menaquinone
- 1.9 Biosynthesis of menaquinone/ based on similarity
- 1.10 Biosynthesis of molybdopterin
- 1.11 Biosynthesis of nad(p)
- 1.12 Biosynthesis of pyridoxal phosphate
- 2 Metabolism of cofactors in SubtiPathways
- 3 Important original publications
- 4 Important reviews
- 5 Back to categories
Genes in this functional category
Biosynthesis/ acquisition of biotin
Biosynthesis/ acquisition of riboflavin/ fad
Biosynthesis/ acquisition of thiamine
Biosynthesis of coenzyme a
Biosynthesis of folate
Biosynthesis of heme/ siroheme
Biosynthesis of lipoic acid (For complete biosynthetic pathway see PubMed)
Biosynthesis of menaquinone
Biosynthesis of menaquinone/ based on similarity
Biosynthesis of molybdopterin
Biosynthesis of nad(p)
Biosynthesis of pyridoxal phosphate
Metabolism of cofactors in SubtiPathways
Important original publications
Miglena Manandhar, John E Cronan
Pimelic acid, the first precursor of the Bacillus subtilis biotin synthesis pathway, exists as the free acid and is assembled by fatty acid synthesis.
Mol Microbiol: 2017, 104(4);595-607
[PubMed:28196402]
[WorldCat.org]
[DOI]
(I p)
Fabian M Commichau, Ariane Alzinger, Rafael Sande, Werner Bretzel, Frederik M Meyer, Bastien Chevreux, Markus Wyss, Hans-Peter Hohmann, Zoltán Prágai
Overexpression of a non-native deoxyxylulose-dependent vitamin B6 pathway in Bacillus subtilis for the production of pyridoxine.
Metab Eng: 2014, 25;38-49
[PubMed:24972371]
[WorldCat.org]
[DOI]
(I p)
Important reviews
Jonathan Rosenberg, Till Ischebeck, Fabian M Commichau
Vitamin B6 metabolism in microbes and approaches for fermentative production.
Biotechnol Adv: 2017, 35(1);31-40
[PubMed:27890703]
[WorldCat.org]
[DOI]
(I p)
John E Cronan
Assembly of Lipoic Acid on Its Cognate Enzymes: an Extraordinary and Essential Biosynthetic Pathway.
Microbiol Mol Biol Rev: 2016, 80(2);429-50
[PubMed:27074917]
[WorldCat.org]
[DOI]
(I e)
Susanne Katharina Schwechheimer, Enoch Y Park, José Luis Revuelta, Judith Becker, Christoph Wittmann
Biotechnology of riboflavin.
Appl Microbiol Biotechnol: 2016, 100(5);2107-19
[PubMed:26758294]
[WorldCat.org]
[DOI]
(I p)
Markus Birkenmeier, Susanne Neumann, Thorsten Röder
Kinetic modeling of riboflavin biosynthesis in Bacillus subtilis under production conditions.
Biotechnol Lett: 2014, 36(5);919-28
[PubMed:24442413]
[WorldCat.org]
[DOI]
(I p)
Tadhg P Begley, Steven E Ealick, Fred W McLafferty
Thiamin biosynthesis: still yielding fascinating biological chemistry.
Biochem Soc Trans: 2012, 40(3);555-60
[PubMed:22616866]
[WorldCat.org]
[DOI]
(I p)
Charles A Abbas, Andriy A Sibirny
Genetic control of biosynthesis and transport of riboflavin and flavin nucleotides and construction of robust biotechnological producers.
Microbiol Mol Biol Rev: 2011, 75(2);321-60
[PubMed:21646432]
[WorldCat.org]
[DOI]
(I p)
Steven Lin, John E Cronan
Closing in on complete pathways of biotin biosynthesis.
Mol Biosyst: 2011, 7(6);1811-21
[PubMed:21437340]
[WorldCat.org]
[DOI]
(I p)
Christopher T Jurgenson, Tadhg P Begley, Steven E Ealick
The structural and biochemical foundations of thiamin biosynthesis.
Annu Rev Biochem: 2009, 78;569-603
[PubMed:19348578]
[WorldCat.org]
[DOI]
(I p)
Tadhg P Begley, Abhishek Chatterjee, Jeremiah W Hanes, Amrita Hazra, Steven E Ealick
Cofactor biosynthesis--still yielding fascinating new biological chemistry.
Curr Opin Chem Biol: 2008, 12(2);118-25
[PubMed:18314013]
[WorldCat.org]
[DOI]
(P p)
Ethan Settembre, Tadhg P Begley, Steven E Ealick
Structural biology of enzymes of the thiamin biosynthesis pathway.
Curr Opin Struct Biol: 2003, 13(6);739-47
[PubMed:14675553]
[WorldCat.org]
[DOI]
(P p)
A Marquet, B T Bui, D Florentin
Biosynthesis of biotin and lipoic acid.
Vitam Horm: 2001, 61;51-101
[PubMed:11153271]
[WorldCat.org]
[DOI]
(P p)
T P Begley, D M Downs, S E Ealick, F W McLafferty, A P Van Loon, S Taylor, N Campobasso, H J Chiu, C Kinsland, J J Reddick, J Xi
Thiamin biosynthesis in prokaryotes.
Arch Microbiol: 1999, 171(5);293-300
[PubMed:10382260]
[WorldCat.org]
[DOI]
(P p)
