Difference between revisions of "SpoIIAA"

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|colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://subtiwiki.uni-goettingen.de/interact/ ''Subt''Interact]''': [http://subtiwiki.uni-goettingen.de/interact/index.php?protein=SpoIIAA SpoIIAA]
 
|colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://subtiwiki.uni-goettingen.de/interact/ ''Subt''Interact]''': [http://subtiwiki.uni-goettingen.de/interact/index.php?protein=SpoIIAA SpoIIAA]
 
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/stress_response.html Stress]'''
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/subtipathways/search.php?enzyme=spoIIAA spoIIAA]'''
 
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|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 12 kDa, 5.855   
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 12 kDa, 5.855   

Revision as of 11:08, 7 January 2014

  • Description: anti-anti-SigF

Gene name spoIIAA
Synonyms
Essential no
Product anti-anti-SigF
Function control of SigF activity
Gene expression levels in SubtiExpress: spoIIAA
Interactions involving this protein in SubtInteract: SpoIIAA
Metabolic function and regulation of this protein in SubtiPathways:
spoIIAA
MW, pI 12 kDa, 5.855
Gene length, protein length 351 bp, 117 aa
Immediate neighbours spoIIAB, dacF
Sequences Protein DNA DNA_with_flanks
Genetic context
SpoIIAA context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
SpoIIAA expression.png















Categories containing this gene/protein

sigma factors and their control, sporulation proteins, phosphoproteins

This gene is a member of the following regulons

AbrB regulon, SigF regulon, SigG regulon, SigH regulon, SinR regulon, Spo0A regulon

The gene

Basic information

  • Locus tag: BSU23470

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: anti-sigma-factor antagonist family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 1TIL (complex with SpoIIAB, Geobacillus stearothermophilus), 1AUZ (NMR)
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation: repressed by glucose (5.2-fold) PubMed, dacF: expressed during sporulation, spoIIAA: expressed early during sporulation
    • expressed under conditions that trigger sporulation (Spo0A) PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Modeling of SigF activation

Georgios Fengos, Dagmar Iber
Prediction stability in a data-based, mechanistic model of σF regulation during sporulation in Bacillus subtilis.
Sci Rep: 2013, 3;2755
[PubMed:24067622] [WorldCat.org] [DOI] (I e)

Dagmar Iber
Inferring Biological Mechanisms by Data-Based Mathematical Modelling: Compartment-Specific Gene Activation during Sporulation in Bacillus subtilis as a Test Case.
Adv Bioinformatics: 2011, 2011;124062
[PubMed:22312331] [WorldCat.org] [DOI] (I p)

Jin Hwan Do, Masao Nagasaki, Satoru Miyano
The systems approach to the prespore-specific activation of sigma factor SigF in Bacillus subtilis.
Biosystems: 2010, 100(3);178-84
[PubMed:20298743] [WorldCat.org] [DOI] (I p)

Original Publications