Difference between revisions of "DhbA"

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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[dhbC]]'', ''[[besA]]''
 
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[dhbC]]'', ''[[besA]]''
 
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|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU32000 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU32000 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU32000 Advanced_DNA]
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|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU32000 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU32000 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU32000 DNA_with_flanks]
 
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Revision as of 11:10, 14 May 2013

  • Description: 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase

Gene name dhbA
Synonyms entA
Essential no
Product 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
Function biosynthesis of the siderophore bacillibactin
Gene expression levels in SubtiExpress: dhbA
MW, pI 27 kDa, 5.311
Gene length, protein length 783 bp, 261 aa
Immediate neighbours dhbC, besA
Sequences Protein DNA DNA_with_flanks
Genetic context
DhbA context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
DhbA expression.png


























Categories containing this gene/protein

acquisition of iron, iron metabolism

This gene is a member of the following regulons

AbrB regulon, Fur regulon

The gene

Basic information

  • Locus tag: BSU32000

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH (according to Swiss-Prot)
  • Protein family: short-chain dehydrogenases/reductases (SDR) family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information:
    • The mRNA has a long 5' leader region. This may indicate RNA-based regulation PubMed
    • the amount of the mRNA is substantially decreased upon depletion of RNase Y PubMed

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Additional publications: PubMed

Lehnik-Habrink M, Schaffer M, Mäder U, Diethmaier C, Herzberg C, Stülke J  
RNA processing in Bacillus subtilis: identification of targets of the essential RNase Y. 
Mol Microbiol. 2011 81(6): 1459-1473. 
PubMed:21815947