Difference between revisions of "ThiF"

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|style="background:#ABCDEF;" align="center"|'''Function''' || biosynthesis of thiamine
 
|style="background:#ABCDEF;" align="center"|'''Function''' || biosynthesis of thiamine
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/thiamin.html Thiamin synthesis]'''
 
 
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|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 36 kDa, 5.619   
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 36 kDa, 5.619   

Revision as of 10:43, 16 February 2010

  • Description: hydroxyethylthiazole phosphate biosynthesis

Gene name thiF
Synonyms yjbU
Essential no
Product unknown
Function biosynthesis of thiamine
MW, pI 36 kDa, 5.619
Gene length, protein length 1008 bp, 336 aa
Immediate neighbours thiG, thiD
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
ThiF context.gif
This image was kindly provided by SubtiList



The gene

Basic information

  • Locus tag: BSU11700

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s): MoeB

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization:

Database entries

  • Structure: 1ZFN (from E. coli, 35% identity, 51% similarity) PubMed
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Christopher T Jurgenson, Tadhg P Begley, Steven E Ealick
The structural and biochemical foundations of thiamin biosynthesis.
Annu Rev Biochem: 2009, 78;569-603
[PubMed:19348578] [WorldCat.org] [DOI] (I p)

Original publications