SivA

• Description: inhibitor of KinA autophosphorylation, and subsequently of entry into sporulation
  
  

Gene name	yweA
Synonyms	ipa-74d
Essential	no
Product	inhibitor of KinA autophosphorylation
Function	control of entry into sporulation via the phosphorelay
Gene expression levels in SubtiExpress: sivA
MW, pI	16 kDa, 7.175
Gene length, protein length	462 bp, 154 aa
Immediate neighbours	rocG, spsL
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

phosphorelay

This gene is a member of the following regulons

AbrB regulon

The gene

Basic information

• Locus tag: BSU37800

Phenotypes of a mutant

• the sivA bslA double mutant exhibits a more severe loss of repellency of the biofilm surface as compared to the bslA mutant PubMed

Database entries

• BsubCyc: BSU37800

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:
  • inhibits KinA autophophorylation PubMed

• Protein family:

• Paralogous protein(s): BslA

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:
  • membrane (according to Swiss-Prot)
  • extracellular (signal peptide) PubMed

Database entries

• BsubCyc: BSU37800

• Structure:

• UniProt: P39632

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: sivA PubMed

• Expression browser: sivA PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:
  • AbrB: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: