YveA

• Description: aspartate/ glutamate transporter
  
  

Gene name	yveA
Synonyms
Essential	no
Product	aspartate/ glutamate transporter
Function	aspartate uptake
Gene expression levels in SubtiExpress: yveA
Metabolic function and regulation of this protein in SubtiPathways: YveA
MW, pI	56 kDa, 9.675
Gene length, protein length	1560 bp, 520 aa
Immediate neighbours	levB, yvdT
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

transporters/ other, biosynthesis/ acquisition of amino acids, utilization of amino acids, sporulation proteins, membrane proteins

This gene is a member of the following regulons

DegU regulon, SacY regulon

The gene

Basic information

• Locus tag: BSU34470

Database entries

• BsubCyc: BSU34470

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:
  • amino acid, polyamine, organocation (APC) superfamily of transporters, TC 2.A.3

• Paralogous protein(s): YbeC

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:
  • cell membrane (according to Swiss-Prot)

Database entries

• BsubCyc: BSU34470

• Structure:

• UniProt: O07002

• KEGG entry: [2]

• T.C. number: 2.A.3.11.1

Expression and regulation

• Operon:
  • sacB-levB-yveA PubMed
  • yveA PubMed

• Expression browser: yveA PubMed

• Sigma factor:
  • sacB: SigA PubMed
  • yveA: SigG PubMed

• Regulation:
  • induction by sucrose (at high concentration) (SacY) PubMed
  • expressed during sporulation in the forespore (SigG) PubMed

• Regulatory mechanism:
  • SacY: binding to a RNA switch (transcriptional antitermination) PubMed
  • DegU-P: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Stephanie T Wang, Barbara Setlow, Erin M Conlon, Jessica L Lyon, Daisuke Imamura, Tsutomu Sato, Peter Setlow, Richard Losick, Patrick Eichenberger
The forespore line of gene expression in Bacillus subtilis.
J Mol Biol: 2006, 358(1);16-37
[PubMed:16497325] [WorldCat.org] [DOI] (P p)

Graciela Lorca, Brit Winnen, Milton H Saier
Identification of the L-aspartate transporter in Bacillus subtilis.
J Bacteriol: 2003, 185(10);3218-22
[PubMed:12730183] [WorldCat.org] [DOI] (P p)

Y Pereira, M F Petit-Glatron, R Chambert
yveB, Encoding endolevanase LevB, is part of the sacB-yveB-yveA levansucrase tricistronic operon in Bacillus subtilis.
Microbiology (Reading): 2001, 147(Pt 12);3413-9
[PubMed:11739774] [WorldCat.org] [DOI] (P p)

S Aymerich, M Steinmetz
Cloning and preliminary characterization of the sacS locus from Bacillus subtilis which controls the regulation of the exoenzyme levansucrase.
Mol Gen Genet: 1987, 208(1-2);114-20
[PubMed:3039303] [WorldCat.org] [DOI] (P p)

H Shimotsu, D J Henner
Modulation of Bacillus subtilis levansucrase gene expression by sucrose and regulation of the steady-state mRNA level by sacU and sacQ genes.
J Bacteriol: 1986, 168(1);380-8
[PubMed:2428811] [WorldCat.org] [DOI] (P p)