SdpC

• Description: toxin, collapses the proton motive force and induces autolysis, kills non-sporulating cells, induces activity of SigW
  
  

Gene name	sdpC
Synonyms	yvaY
Essential	no
Product	toxin, kills non-sporulating cells
Function	killing of non-sporulating sister cells
Gene expression levels in SubtiExpress: sdpC
Interactions involving this protein in SubtInteract: SdpC
MW, pI	22 kDa, 9.611
Gene length, protein length	609 bp, 203 aa
Immediate neighbours	sdpB, sdpI
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

toxins, antitoxins and immunity against toxins

This gene is a member of the following regulons

AbrB regulon, Rok regulon, Spo0A regulon

The gene

Basic information

• Locus tag: BSU33770

Database entries

• BsubCyc: BSU33770

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:
  • toxin, collapses the proton motive force and induces autolysis PubMed

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification: the meture SDP is a 42-residue peptide with one disulfide bridge PubMed

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • CsaA-SdpC PubMed

• Localization: secreted (according to Swiss-Prot)

Database entries

• BsubCyc: BSU33770

• Structure:

• UniProt: O34344

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: sdpA-sdpB-sdpC PubMed

• Expression browser: sdpC PubMed

• Sigma factor:

• Regulation:
  • repressed by casamino acids PubMed
  • expressed under conditions that trigger sporulation (Spo0A) PubMed
  • repressed by Rok PubMed
  • repressed during logrithmic growth (AbrB) PubMed

• Regulatory mechanism:
  • Spo0A: transcription activation PubMed
  • Rok: transcription repression PubMed
  • AbrB: transcription repression PubMed

• Additional information:
  • the amount of the mRNA is substantially decreased upon depletion of RNase Y PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

José Eduardo González-Pastor
Cannibalism: a social behavior in sporulating Bacillus subtilis.
FEMS Microbiol Rev: 2011, 35(3);415-24
[PubMed:20955377] [WorldCat.org] [DOI] (I p)