SplA

• Description: transcriptional repressor of the spore photoproduct lyase splA-splB operon
  
  

Gene name	splA
Synonyms	ykxI
Essential	no
Product	transcriptional regulator
Function	regulation of the splA-splB operon
Gene expression levels in SubtiExpress: splA
MW, pI	9 kDa, 4.419
Gene length, protein length	237 bp, 79 aa
Immediate neighbours	ptsI, splB
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

DNA repair/ recombination, transcription factors and their control, sporulation proteins

This gene is a member of the following regulons

SigG regulon

The gene

Basic information

• Locus tag: BSU13920

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: P37955

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: splA-splB PubMed

• Expression browser: splA PubMed

• Sigma factor: SigG PubMed

• Regulation: expressed during sporulation in the forespore (SigG) PubMed

• Regulatory mechanism:
  • negative autoregulation by SplA PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

Alhosna Benjdia
DNA photolyases and SP lyase: structure and mechanism of light-dependent and independent DNA lyases.
Curr Opin Struct Biol: 2012, 22(6);711-20
[PubMed:23164663] [WorldCat.org] [DOI] (I p)

Structure of the spore photoproduct lesion in DNA

Isha Singh, Yajun Jian, Lei Li, Millie M Georgiadis
The structure of an authentic spore photoproduct lesion in DNA suggests a basis for recognition.
Acta Crystallogr D Biol Crystallogr: 2014, 70(Pt 3);752-9
[PubMed:24598744] [WorldCat.org] [DOI] (I p)