YflA

• Description: general stress protein, similar to amino acid carrier protein, required for protection against paraquat stress
  
  

Gene name	yflA
Synonyms
Essential	no
Product	unknown
Function	protection against paraquat stress
Gene expression levels in SubtiExpress: yflA
MW, pI	50 kDa, 9.856
Gene length, protein length	1413 bp, 471 aa
Immediate neighbours	yflB, yfkT
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

transporters/ other, general stress proteins (controlled by SigB), resistance against oxidative and electrophile stress, membrane proteins

This gene is a member of the following regulons

Abh regulon, AbrB regulon, SigB regulon

The gene

Basic information

• Locus tag: BSU07750

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:
  • cell membrane (according to UniProt)

Database entries

• Structure:

• UniProt: O34708

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Expression browser: yflA PubMed

• Sigma factor: SigB PubMed

• Regulation:
  • induced by stress (SigB) PubMed
  • Abh and AbrB: synergistic transcription repressionPubMed

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Alexander Reder, Dirk Höper, Ulf Gerth, Michael Hecker
Contributions of individual σB-dependent general stress genes to oxidative stress resistance of Bacillus subtilis.
J Bacteriol: 2012, 194(14);3601-10
[PubMed:22582280] [WorldCat.org] [DOI] (I p)

Onuma Chumsakul, Hiroki Takahashi, Taku Oshima, Takahiro Hishimoto, Shigehiko Kanaya, Naotake Ogasawara, Shu Ishikawa
Genome-wide binding profiles of the Bacillus subtilis transition state regulator AbrB and its homolog Abh reveals their interactive role in transcriptional regulation.
Nucleic Acids Res: 2011, 39(2);414-28
[PubMed:20817675] [WorldCat.org] [DOI] (I p)

Dirk Höper, Uwe Völker, Michael Hecker
Comprehensive characterization of the contribution of individual SigB-dependent general stress genes to stress resistance of Bacillus subtilis.
J Bacteriol: 2005, 187(8);2810-26
[PubMed:15805528] [WorldCat.org] [DOI] (P p)