ParA

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  • Description: ATPase, centromere-like function involved in forespore chromosome partitioning / negative regulation of sporulation initiation

Gene name soj
Synonyms spo0JA
Essential no
Product negative regulator of sporulation initiation
Function forespore chromosome partitioning /
negative regulation of sporulation initiation
Gene expression levels in SubtiExpress: soj
Interactions involving this protein in SubtInteract: Soj
MW, pI 27 kDa, 4.903
Gene length, protein length 759 bp, 253 aa
Immediate neighbours spo0J, yyaB
Sequences Protein DNA DNA_with_flanks
Genetic context
Soj context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
Soj expression.png















Categories containing this gene/protein

DNA condensation/ segregation, sporulation/ other, membrane proteins

This gene is a member of the following regulons

Spo0A regulon

The gene

Basic information

  • Locus tag: BSU40970

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Protein family: parA family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
    • Spo0J inhibits Soj dimerization and concomitant DNA-binding activity by stimulating Soj ATPase activity PubMed

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • repressed under conditions that trigger sporulation (Spo0A) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Rodrigo Reyes-Lamothe, Emilien Nicolas, David J Sherratt
Chromosome replication and segregation in bacteria.
Annu Rev Genet: 2012, 46;121-43
[PubMed:22934648] [WorldCat.org] [DOI] (I p)

Tsutomu Katayama, Shogo Ozaki, Kenji Keyamura, Kazuyuki Fujimitsu
Regulation of the replication cycle: conserved and diverse regulatory systems for DnaA and oriC.
Nat Rev Microbiol: 2010, 8(3);163-70
[PubMed:20157337] [WorldCat.org] [DOI] (I p)

Original publications