parA
168

ATPase, centromere-like function involved in forespore chromosome partitioning / negative regulation of Sporulation initiation, regulator of SMC complex dynamics

Locus

BSU_40970

Molecular weight

27.39 kDa

Isoelectric point

4.9

Protein length

253 aaSequenceBlast

Gene length

762 bpSequenceBlast

Function

forespore chromosome partitioning / negative regulation of Sporulation initiation

Product

negative regulator of Sporulation initiation

Essential

Synonyms

parA, soj, spo0JA

Outlinks

BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Hide small RNAsZoom:

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1192 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene

Coordinates

4,206,397 4,207,158

Phenotypes of a mutant

defective in oriC segregation during Sporulation PubMed

The protein

Catalyzed reaction/ biological activity

regulates DNA replication initiation by either inhibiting or activating the DNA replication initiator protein DnaA PubMed; regulation of Spo0A expression PubMed

has ATPase activity PubMed

Protein family

ParA family (with FlhG and MinD, according to UniProt)

Structure

5U1G (PDB) PubMed

5U1J (PDB) PubMed

P37522 (AlphaFold)

Effectors of protein activity

ParB inhibits ParA dimerization and concomitant DNA-binding activity by stimulating ParA ATPase activity PubMed

Interactions

exists as ATP-bound dimer an ADP-bound monomer PubMed

Localization