TrxA
- Description: antioxidative action by facilitating the reduction of other proteins by cysteine thiol-disulfide exchange
Gene name | trxA |
Synonyms | trx |
Essential | yes PubMed |
Product | thioredoxin |
Function | protection of proteins against oxidative damage |
Gene expression levels in SubtiExpress: trxA | |
Interactions involving this protein in SubtInteract: TrxA | |
MW, pI | 11 kDa, 4.308 |
Gene length, protein length | 312 bp, 104 aa |
Immediate neighbours | uvrC, abf2 |
Sequences | Protein DNA DNA_with_flanks |
Genetic context This image was kindly provided by SubtiList
| |
Expression at a glance PubMed |
Contents
Categories containing this gene/protein
electron transport/ other, general stress proteins (controlled by SigB), resistance against oxidative and electrophile stress, essential genes
This gene is a member of the following regulons
CtsR regulon, SigB regulon, Spx regulon
The gene
Basic information
- Locus tag: BSU28500
Phenotypes of a mutant
essential PubMed
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: thioredoxin family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization: cytoplasm PubMed
Database entries
- UniProt: P14949
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Operon: trxA PubMed
- Regulation:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Reviews
Jun Lu, Arne Holmgren
The thioredoxin antioxidant system.
Free Radic Biol Med: 2014, 66;75-87
[PubMed:23899494]
[WorldCat.org]
[DOI]
(I p)
Original publications