SdpI

• Description: immunity protein, protection against SdpC
  
  

Gene name	sdpI
Synonyms	yvaZ
Essential	no
Product	immunity protein
Function	protection against SdpC
Gene expression levels in SubtiExpress: sdpI
Interactions involving this protein in SubtInteract: SdpI
MW, pI	23 kDa, 9.61
Gene length, protein length	621 bp, 207 aa
Immediate neighbours	sdpC, sdpR
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

toxins, antitoxins and immunity against toxins, membrane proteins

This gene is a member of the following regulons

AbrB regulon, SdpR regulon

The gene

Basic information

• Locus tag: BSU33780

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s): YfhL, YbgB

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity: in the presence of extracellular SdpC, SdpI binds and sequesters SdpR , this results in induction of the sdpR-sdpI operon PubMed

• Interactions:
  • SdpI-SdpR PubMed

• Localization: membrane (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: O32241

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: sdpR-sdpI PubMed

• Expression browser: sdpI PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • repressed during logrithmic growth (AbrB) PubMed
  • induced by extracellular SdpC (SdpR) PubMed

• Regulatory mechanism:
  • AbrB: transcription repression PubMed
  • SdpR: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Original Publications

Tatyana Leonidovna Povolotsky, Ekaterina Orlova, Dorjee G Tamang, Milton H Saier
Defense against cannibalism: the SdpI family of bacterial immunity/signal transduction proteins.
J Membr Biol: 2010, 235(3);145-62
[PubMed:20563570] [WorldCat.org] [DOI] (I p)

Craig D Ellermeier, Errett C Hobbs, Jose E Gonzalez-Pastor, Richard Losick
A three-protein signaling pathway governing immunity to a bacterial cannibalism toxin.
Cell: 2006, 124(3);549-59
[PubMed:16469701] [WorldCat.org] [DOI] (P p)

José E González-Pastor, Errett C Hobbs, Richard Losick
Cannibalism by sporulating bacteria.
Science: 2003, 301(5632);510-3
[PubMed:12817086] [WorldCat.org] [DOI] (I p)