AcuA

• Description: protein acetylase for the control of AcsA activity
  
  

Gene name	acuA
Synonyms
Essential	no
Product	Gcn5-related N-acetyltransferase
Function	control of AcsA activity
Gene expression levels in SubtiExpress: acuA
MW, pI	24 kDa, 5.028
Gene length, protein length	630 bp, 210 aa
Immediate neighbours	acsA, acuB
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

utilization of specific carbon sources, utilization of lipids, protein modification

This gene is a member of the following regulons

CcpA regulon

The gene

Basic information

• Locus tag: BSU29690

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: acetylates (and thereby inactivates) AcsA on Lys-549 PubMed PubMed

• Protein family: acetyltransferase family (according to Swiss-Prot) Gcn5-relatedN-acetyltransferase PubMed

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: P39065

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: acuA-acuB-acuC PubMed

• Expression browser: acuA PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • repressed by glucose (3.4-fold) (CcpA) PubMed

• Regulatory mechanism:
  • CcpA: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:
  • GP1211 (acuA::kan), available in Jörg Stülke's lab
  • GP1255 (acuA::kan yjcK::cat ynaD::spec yoaA::tet), available in Jörg Stülke's lab

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: