BacD

• Description: alanine-anticapsin ligase
  
  

Gene name	bacD
Synonyms	ywfE, ipa-83d
Essential	no
Product	alanine-anticapsin ligase
Function	biosynthesis of the antibiotic bacilysin
Gene expression levels in SubtiExpress: bacD
MW, pI	52 kDa, 4.679
Gene length, protein length	1416 bp, 472 aa
Immediate neighbours	bacE, bacC
Sequences	Protein DNA Advanced_DNA
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

miscellaneous metabolic pathways, biosynthesis of antibacterial compounds

This gene is a member of the following regulons

AbrB regulon, CodY regulon, ScoC regulon

The gene

Basic information

• Locus tag: BSU37710

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:
  • ligation of anticapsin to L-Ala to form bacilysin, ultimate step in bacilysin biosynthesis PubMed

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure: 3VMM PubMed

• UniProt: P39641

• KEGG entry: [2]

• E.C. number: 6.3.2.28

Expression and regulation

• Operon: bacA-bacB-bacC-bacD-bacE-bacF PubMed

• Expression browser: bacD PubMed

• Sigma factor: SigA PubMed

• Regulation:

• Regulatory mechanism:
  • CodY: transcription repression PubMed
  • AbrB: transcription repression PubMed
  • ScoC: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Additional publications: PubMed