PspA

• Description: phage shock protein A homolog
  
  

Gene name	pspA
Synonyms	ydjF
Essential	no
Product	unknown
Function	unknown
Gene expression levels in SubtiExpress: pspA
MW, pI	24 kDa, 5.775
Gene length, protein length	681 bp, 227 aa
Immediate neighbours	fruC, ydjG
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

cell envelope stress proteins (controlled by SigM, V, W, X, Y), membrane proteins

This gene is a member of the following regulons

AbrB regulon, SigW regulon

The gene

Basic information

• Locus tag: BSU06180

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: pspA/IM30 family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: membrane protein

Database entries

• Structure:

• UniProt: P54617

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: pspA-ydjG-ydjH-ydjI PubMed

• Expression browser: pspA PubMed

• Sigma factor: SigW PubMed

• Regulation:
  • induced by alkaline shock (SigW) PubMed
  • repressed during logarithmic phase (AbrB) PubMed
  • induced by antibiotics interacting with the cytoplasmic membrane PubMed

• Regulatory mechanism:
  • AbrB: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Michaela Wenzel, Bastian Kohl, Daniela Münch, Nadja Raatschen, H Bauke Albada, Leendert Hamoen, Nils Metzler-Nolte, Hans-Georg Sahl, Julia E Bandow
Proteomic response of Bacillus subtilis to lantibiotics reflects differences in interaction with the cytoplasmic membrane.
Antimicrob Agents Chemother: 2012, 56(11);5749-57
[PubMed:22926563] [WorldCat.org] [DOI] (I p)

Allison V Banse, Arnaud Chastanet, Lilah Rahn-Lee, Errett C Hobbs, Richard Losick
Parallel pathways of repression and antirepression governing the transition to stationary phase in Bacillus subtilis.
Proc Natl Acad Sci U S A: 2008, 105(40);15547-52
[PubMed:18840696] [WorldCat.org] [DOI] (I p)

T Wiegert, G Homuth, S Versteeg, W Schumann
Alkaline shock induces the Bacillus subtilis sigma(W) regulon.
Mol Microbiol: 2001, 41(1);59-71
[PubMed:11454200] [WorldCat.org] [DOI] (P p)