LevR

• Description: transcriptional activator of the levD-levE-levF-levG-sacC operon
  
  

Gene name	levR
Synonyms
Essential	no
Product	transcriptional activator, PRD-type (for SigL-dependent promoter)
Function	regulation of levan and fructose utilization
Interactions involving this protein in SubtInteract: LevR
Metabolic function and regulation of this protein in SubtiPathways: Sugar catabolism
MW, pI	105 kDa, 5.943
Gene length, protein length	2814 bp, 938 aa
Immediate neighbours	levD, aapA
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

utilization of specific carbon sources, transcription factors and their control, phosphoproteins

The LevR regulon:

• levD-levE-levF-levG-sacC

The gene

Basic information

• Locus tag: BSU27080

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: binding to the upstream activating sequence in front of the levD gene results in activation of transcription of the levD-levE-levF-levG-sacC operon, bining occurs in the presence of fructose

• Protein family: transcriptional antiterminator bglG family (according to Swiss-Prot), Attention: this is wrong: LicR is a transcription activator, the similarity to the BglG family is limited to the PTS-regulation domains

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • PtsH-LevR
  • LevE-LevR
  • LevR-SigL

• Localization: cytoplasm (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: P23914

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Expression browser: levR PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: