Rok

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  • Description: repressor of comK, nucleoid associated protein that serves to help repress expression of A+T-rich genes, many of which appear to have been acquired by horizontal gene transfer

Gene name rok
Synonyms ykuW
Essential no
Product transcriptional repressor
Function regulation of genetic competence
Metabolic function and regulation of this protein in SubtiPathways:
Protein secretion
MW, pI 21 kDa, 9.701
Gene length, protein length 573 bp, 191 aa
Immediate neighbours ykuV, yknT
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
Rok context.gif
This image was kindly provided by SubtiList




Categories containing this gene/protein

genetic competence, transcription factors and their control

This gene is a member of the following regulons

AbrB regulon, Rok regulon, SinR regulon, Spo0A regulon

The Rok regulon

The gene

Basic information

  • Locus tag: BSU14240

Phenotypes of a mutant

higher excision rate of the conjugative transposon ICEBs1 PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: binds to extended regions of the B. subtilis genome that are characterized by a high A+T content and are known or believed to have been acquired by horizontal gene transfer PubMed
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Daniel Schultz, Peter G Wolynes, Eshel Ben Jacob, José N Onuchic
Deciding fate in adverse times: sporulation and competence in Bacillus subtilis.
Proc Natl Acad Sci U S A: 2009, 106(50);21027-34
[PubMed:19995980] [WorldCat.org] [DOI] (I p)

Original Publications

Additional publications: PubMed