SdpC

• Description: toxin, kills non-sporulating cells, induces activity of SigW
  
  

Gene name	sdpC
Synonyms	yvaY
Essential	no
Product	toxin, kills non-sporulating cells
Function	killing of non-sporulating sister cells
Interactions involving this protein in SubtInteract: SdpC
MW, pI	22 kDa, 9.611
Gene length, protein length	609 bp, 203 aa
Immediate neighbours	sdpB, sdpI
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

toxins, antitoxins and immunity against toxins

This gene is a member of the following regulons

AbrB regulon, Rok regulon, Spo0A regulon

The gene

Basic information

• Locus tag: BSU33770

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification: the meture SDP is a 42-residue peptide with one disulfide bridge PubMed

• Cofactor(s):

• Effectors of protein activity:

• Interactions: CsaA-SdpC PubMed

• Localization: secreted (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: O34344

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: sdpA-sdpB-sdpC PubMed

• Sigma factor:

• Regulation:
  • repressed by casamino acids PubMed
  • expressed under conditions that trigger sporulation (Spo0A) PubMed
  • repressed by Rok PubMed
  • repressed during logrithmic growth (AbrB) PubMed

• Regulatory mechanism:
  • Spo0A: transcription activation PubMed
  • Rok: transcription repression PubMed
  • AbrB: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

José Eduardo González-Pastor
Cannibalism: a social behavior in sporulating Bacillus subtilis.
FEMS Microbiol Rev: 2011, 35(3);415-24
[PubMed:20955377] [WorldCat.org] [DOI] (I p)

Original Publications

Additional publications: PubMed