Sandbox

• Description: regulation of degradative enzyme production
  
  

Gene name	degR
Synonyms	prtR
Essential	no
Product	positive effector of DegU-phosphate stability
Function	control of DegU activity
MW, pI	6 kDa, 5.158
Gene length, protein length	180 bp, 60 aa
Immediate neighbours	cspD, ypzA
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU21940

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cytoplasm (according to Swiss-Prot)

Database entries

• Structure:

• Swiss prot entry: P68731

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: degR

• Sigma factor: SigD

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

M Ogura, Y Ohshiro, S Hirao, T Tanaka
A new Bacillus subtilis gene, med, encodes a positive regulator of comK.
J Bacteriol: 1997, 179(20);6244-53
[PubMed:9335269] [WorldCat.org] [DOI] (P p)

M Ogura, T Tanaka
Bacillus subtilis ComK negatively regulates degR gene expression.
Mol Gen Genet: 1997, 254(2);157-65
[PubMed:9108277] [WorldCat.org] [DOI] (P p)

M Ogura, T Tanaka
Transcription of Bacillus subtilis degR is sigma D dependent and suppressed by multicopy proB through sigma D.
J Bacteriol: 1996, 178(1);216-22
[PubMed:8550420] [WorldCat.org] [DOI] (P p)

K Mukai, M Kawata-Mukai, T Tanaka
Stabilization of phosphorylated Bacillus subtilis DegU by DegR.
J Bacteriol: 1992, 174(24);7954-62
[PubMed:1459944] [WorldCat.org] [DOI] (P p)

M Yang, H Shimotsu, E Ferrari, D J Henner
Characterization and mapping of the Bacillus subtilis prtR gene.
J Bacteriol: 1987, 169(1);434-7
[PubMed:3098734] [WorldCat.org] [DOI] (P p)

1. Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed