T-box

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The T-box element is an RNA switch that controls genes involved in amino acid metabolism.

In the absence of an amino acid, the uncharged tRNA binds the T-box region in the leader region of the mRNA of the controlled gene/ operon and thereby prevents the formation of a transcription terminator. The result is gene expression of the target gene in the absence of the specific amino acid.

Complete list of genes controlled by T-box elements

  • Induction by alanine limitation
  • Induction by aspartate limitation
  • Induction by histidine limitation
  • Induction by phenyalanine limitation
  • Induction by serine limitation
  • Induction by threonine limitation
  • Induction by tyrosine limitation

Reviews on T-box regulation