MalR

• Description: two-component response regulator, regulation of malate uptake
  
  

Gene name	malR
Synonyms	yufM
Essential	no
Product	two-component response regulator
Function	regulation of malate uptake
Gene expression levels in SubtiExpress: malR
Interactions involving this protein in SubtInteract: MalR
Metabolic function and regulation of this protein in SubtiPathways: Central C-metabolism
MW, pI	26 kDa, 5.976
Gene length, protein length	705 bp, 235 aa
Immediate neighbours	malK, nupN
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

utilization of specific carbon sources, transcription factors and their control, phosphoproteins

The MalR regulon:

• maeA-ywkB, maeN, yflS

The gene

Basic information

• Locus tag: BSU31530

Phenotypes of a mutant

unable to use malate as the single carbon source PubMed

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification: phosphorylated by MalK on an Asp residue

• Cofactor(s):

• Effectors of protein activity: phosphorylation likely affects DNA-binding activity

• Interactions:
  • MalK-MalR

• Localization: cytoplasm (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: O05251

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: malR PubMed

• Expression browser: malR PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant: GP1301 (cat), available in Stülke lab

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

Stephane Aymerich, Microbiology and Molecular Genetics, INRA Paris-Grignon, France