yflS

yflS
168

malate transporter

Locus
BSU_07570
Molecular weight
51.27 kDa
Isoelectric point
9.74
Protein length
478 aaSequenceBlast
Gene length
1437 bpSequenceBlast
Function
malate uptake
Product
malate transporter
Essential
no
Synonyms
yflS
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0471 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
829,382  830,818
RNA
Additional information
the mRNA is stabilized by basepairing with the RoxS RNA PubMed
non-protected mRNA is subject to degradation by by RNase J1 PubMed
The protein
Catalyzed reaction/ biological activity
uptake of malate
Protein family
SLC13A/DASS transporter (TC 2.A.47) family (single member, according to UniProt)
Structure
O34726 (AlphaFold)
Localization
cell membrane (according to UniProt)
spore membrane PubMed
Expression and Regulation
Operons
Genes
yflS
Description
PubMed
Regulation
induced by malate (MalR)
Regulatory mechanism
MalR: activation, in malR regulon
Additional information
the mRNA is substantially stabilized upon depletion of RNase Y PubMed
the mRNA is stabilized by basepairing with the RoxS RNA PubMed
non-protected mRNA is subject to degradation by by RNase J1 PubMed
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yflS

2025-03-09 21:45:47

Jstuelk

69

de9eb939a7a13427edcbb1cc8d89877007a9cd2f

F9AB325D8ADE04133ED249F51B3B4792F4CC0ABA

Biological materials
Mutant
MGNA-C249 (yflS::erm), available at the NBRP B. subtilis, Japan
GP1450 (cat), available in Jörg Stülke's lab
BKE07570 (yflS::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATAAATAGGTCTCCTCCTA,  downstream forward: _UP4_TAGAAAGAAAAAGGCAGACG
BKK07570 (yflS::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATAAATAGGTCTCCTCCTA,  downstream forward: _UP4_TAGAAAGAAAAAGGCAGACG
References
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Page visits: 4578

Time of last update: 2025-03-31 05:53:25

Author of last update: Melvin.boenninger