Ugd

• Description: UDP-glucose dehydrogenase
  
  

Gene name	ugd
Synonyms	ywqF
Essential	no
Product	UDP-glucose dehydrogenase
Function	unknown
Gene expression levels in SubtiExpress: ugd
Interactions involving this protein in SubtInteract: Ugd
MW, pI	47 kDa, 5.03
Gene length, protein length	1320 bp, 440 aa
Immediate neighbours	ywqG, ptpZ
Sequences	Protein DNA Advanced_DNA
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

phosphoproteins

The gene

Basic information

• Locus tag: BSU36230

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: UDP-glucose + 2 NAD⁺ + H₂O = UDP-glucuronate + 2 NADH (according to Swiss-Prot)

• Protein family: UDP-glucose/GDP-mannose dehydrogenase family (according to Swiss-Prot)

• Paralogous protein(s): TuaD, YtcA

Extended information on the protein

• Kinetic information:

• Domains:

• Modification: phosphorylation on Tyr-70 by PtkA PubMed, dephosphorylated by PtpZ PubMed

• Cofactor(s):

• Effectors of protein activity: phosphorylation by PtkA stimulates activity of Ugd PubMed

• Interactions:

• Localization: cytoplasm (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: P96718

• KEGG entry: [3]

• E.C. number: 1.1.1.22

Expression and regulation

• Operon: tkmA-ptkA-ptpZ-ugd PubMed

• Expression browser: ugd PubMed

• Sigma factor: SigA PubMed

• Regulation:

• Regulatory mechanism:
  • DegU-P: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: