Fin

• • suppressor of recU mutations, participates in the stabilization and or processing of holliday junction intermediates PubMed
    
  • alternative description: antagonist to SigF, required for the switch from SigF- to SigG-dependent gene expression in the forespore PubMed
    
    

Gene name	subA
Synonyms	yabK
Essential	no
Product	unknown
Function	homologous recombination
Gene expression levels in SubtiExpress: fin
MW, pI	8 kDa, 5.192
Gene length, protein length	228 bp, 76 aa
Immediate neighbours	spoVC, mfd
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

DNA repair/ recombination, sigma factors and their control, sporulation proteins

The gene

Basic information

• Locus tag: BSU00540

Phenotypes of a mutant

sporulation defect (50-fold reduction of viable spore count) and arrest after engulfment PubMed

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • SigF-Fin (probably) PubMed

• Localization: localizes diffusely within the forespore compartment of sporangia at both early and late stages of sporulation, cytosolic protein PubMed

Database entries

• Structure:

• UniProt: P37553

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Expression browser: fin PubMed

• Sigma factor: SigF PubMed, SigG PubMed

• Regulation: expressed in two waves in the forespore (after two hours (SigF) and three hours (SigG) after the onset of sporulation) PubMed

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Begoña Carrasco, M Castillo Cozar, Rudi Lurz, Juan C Alonso, Silvia Ayora
Genetic recombination in Bacillus subtilis 168: contribution of Holliday junction processing functions in chromosome segregation.
J Bacteriol: 2004, 186(17);5557-66
[PubMed:15317759] [WorldCat.org] [DOI] (P p)

B Carrasco, S Fernández, K Asai, N Ogasawara, J C Alonso
Effect of the recU suppressors sms and subA on DNA repair and homologous recombination in Bacillus subtilis.
Mol Genet Genomics: 2002, 266(5);899-906
[PubMed:11810266] [WorldCat.org] [DOI] (P p)

Additional publications: PubMed