YvrI

• Description: RNA polymerase sigma factor YvrI
  
  

Gene name	yvrI
Synonyms	sigO
Essential	no
Product	co-sigma factor with YvrHa
Function	RNA polymerase sigma factor
Interactions involving this protein in SubtInteract: YvrI
MW, pI	20.76 kDa, 9.36
Gene length, protein length	531 bp, 176 aa
Immediate neighbours	yvrHa, yvrJ
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

transcription, sigma factors and their control, acid stress proteins (controlled by YvrI-YvrHa)

This gene is a member of the following regulons

YvrHb regulon, YvrI-YvrHa regulon

The YvrI-YvrHa regulon

• oxdC-yvrL
• yvrI-yvrHa
• yvrJ

The gene

Basic information

• Locus tag: BSU33230

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains: contains a DNA-binding helix-turn-helix motif (HTH) and the region 4.2 of Sigma factors PubMed

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • YvrI-RpoB PubMed
  • YvrI-YvrHa PubMed

• Localization:

Database entries

• Structure:

• UniProt: O34843

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: yvrI-yvrHa PubMed

• Expression browser: yvrI PubMed

• Sigma factor: YvrI-YvrHa PubMed

• Regulation: induced by acidic growth conditions PubMed

• Regulatory mechanism: activated by YvrHb PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

John Helmann, Cornell University, USA Homepage

References

Shawn R MacLellan, Veronica Guariglia-Oropeza, Ahmed Gaballa, John D Helmann
A two-subunit bacterial sigma-factor activates transcription in Bacillus subtilis.
Proc Natl Acad Sci U S A: 2009, 106(50);21323-8
[PubMed:19940246] [WorldCat.org] [DOI] (I p)

Shawn R MacLellan, John D Helmann, Haike Antelmann
The YvrI alternative sigma factor is essential for acid stress induction of oxalate decarboxylase in Bacillus subtilis.
J Bacteriol: 2009, 191(3);931-9
[PubMed:19047353] [WorldCat.org] [DOI] (I p)

Shawn R MacLellan, Tina Wecke, John D Helmann
A previously unidentified sigma factor and two accessory proteins regulate oxalate decarboxylase expression in Bacillus subtilis.
Mol Microbiol: 2008, 69(4);954-67
[PubMed:18573182] [WorldCat.org] [DOI] (I p)

Masakuni Serizawa, Keisuke Kodama, Hiroki Yamamoto, Kazuo Kobayashi, Naotake Ogasawara, Junichi Sekiguchi
Functional analysis of the YvrGHb two-component system of Bacillus subtilis: identification of the regulated genes by DNA microarray and northern blot analyses.
Biosci Biotechnol Biochem: 2005, 69(11);2155-69
[PubMed:16306698] [WorldCat.org] [DOI] (P p)