DisA

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  • Description: DNA integrity scanning protein, delays sporulation in the case of chromosome damage, has diadenylate cyclase activity

Gene name disA
Synonyms yacK
Essential no
Product DNA integrity scanning protein, has diadenylate cyclase activity
Function control of sporulation initiation
Interactions involving this protein in SubtInteract: DisA
Metabolic function and regulation of this protein in SubtiPathways:
Stress
MW, pI 40 kDa, 5.569
Gene length, protein length 1080 bp, 360 aa
Immediate neighbours radA, yacL
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YacK context.gif
This image was kindly provided by SubtiList







Categories containing this gene/protein

cell division, metabolism of signalling nucleotides, sporulation/ other, general stress proteins (controlled by SigB), cell envelope stress proteins (controlled by SigM, W, X, Y), heat shock proteins

This gene is a member of the following regulons

CtsR regulon, SigB regulon, SigM regulon

The gene

Basic information

  • Locus tag: BSU00880

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: synthesizes the small molecule cyclic diadenosine monophosphate (c-di-AMP) PubMed
  • Protein family: disA family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Localization: see a video showing the movement of DisA in the cell (in real time) PubMed

Database entries

  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulatory mechanism: CtsR: transcription repression PubMed
  • Additional information:

Biological materials

  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References