YkuV

• Description: thiol disulfide oxidoreductase
  
  

Gene name	ykuV
Synonyms
Essential	no
Product	thiol disulfide oxidoreductase
Function	protection of proteins against oxidative damage
MW, pI	17 kDa, 6.333
Gene length, protein length	459 bp, 153 aa
Immediate neighbours	ykuU, rok
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU14230

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

Categories containing this gene/protein

resistance against oxidative and electrophile stress

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cytoplasm (according to Swiss-Prot)

Database entries

• Structure: 2B5X (reduced form), 2B5Y (oxidized form)

• UniProt: O31699

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon: ykuU-ykuV PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:
  • AbrB: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Onuma Chumsakul, Hiroki Takahashi, Taku Oshima, Takahiro Hishimoto, Shigehiko Kanaya, Naotake Ogasawara, Shu Ishikawa
Genome-wide binding profiles of the Bacillus subtilis transition state regulator AbrB and its homolog Abh reveals their interactive role in transcriptional regulation.
Nucleic Acids Res: 2011, 39(2);414-28
[PubMed:20817675] [WorldCat.org] [DOI] (I p)

Xinxin Zhang, Yunfei Hu, Xianrong Guo, Ewen Lescop, You Li, Bin Xia, Changwen Jin
The Bacillus subtilis YkuV is a thiol:disulfide oxidoreductase revealed by its redox structures and activity.
J Biol Chem: 2006, 281(12);8296-304
[PubMed:16418167] [WorldCat.org] [DOI] (P p)