DctR

• Description: two-component response regulator, regulation of the dctS-dctR-dctP operon
  
  

Gene name	dctR
Synonyms	ydbG
Essential	no
Product	two-component response regulator
Function	regulation of the dctS-dctR-dctP operon
Metabolic function and regulation of this protein in SubtiPathways: Central C-metabolism
MW, pI	25 kDa, 8.6
Gene length, protein length	678 bp, 226 aa
Immediate neighbours	dctS, dctP
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU04460

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

Categories containing this gene/protein

utilization of specific carbon sources, transcription factors and their control, phosphoproteins

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification: phosphorylated by DctS on an Asp residue

• Cofactor(s):

• Effectors of protein activity: phosphorylation likely affects DNA-binding activity

• Interactions: DctS-DctR

• Localization: cytoplasm (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: P96602

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: dctS-dctR-dctP PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Kei Asai, Sang-Hoon Baik, Yasuhiro Kasahara, Shigeki Moriya, Naotake Ogasawara
Regulation of the transport system for C4-dicarboxylic acids in Bacillus subtilis.
Microbiology (Reading): 2000, 146 ( Pt 2);263-271
[PubMed:10708364] [WorldCat.org] [DOI] (P p)

C Fabret, V A Feher, J A Hoch
Two-component signal transduction in Bacillus subtilis: how one organism sees its world.
J Bacteriol: 1999, 181(7);1975-83
[PubMed:10094672] [WorldCat.org] [DOI] (P p)