dctP
168
uptake of succinate, fumarate, malate and oxaloacetate via proton symport
Locus
BSU_04470
Molecular weight
45.28 kDa
Isoelectric point
8.67
Function
uptake of succinate, fumurate, malate and oxaloacetate
Product
C4-dicarboxylate transport protein
Essential
no
Synonyms
dctP, ydbH, dctA
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1301 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
500,166 501,431
The protein
Catalyzed reaction/ biological activity
uptake of succinate, fumurate, malate and oxaloacetate via proton symport PubMed
Protein family
dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family (according to UniProt)
Structure
4KY0 (PDB) (the glutamate transporter of Thermococcus kodakarensis, 31% identity, 71% similarity) PubMed
Paralogous protein(s)
cell membrane (according to Swiss-Prot)
Expression and Regulation
Operons
Genes
Description
Regulation
Regulatory mechanism
Fur: indirect effect, in fur regulon
Sigma factors
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Other regulations
Biological materials
Mutant
BKE04470 (dctP::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATATCCTTCATCCCCCTGT, downstream forward: _UP4_TGAAAAAAGAACGGCCCATC
BKK04470 (dctP::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATATCCTTCATCCCCCTGT, downstream forward: _UP4_TGAAAAAAGAACGGCCCATC
GP2600 (dctP::tet comIQ12L) (in DK1042) available in Jörg Stülke's lab
GP4218 (dctP::tet), available in Jörg Stülke's lab
References
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Time of last update: 2025-03-31 16:13:53
Author of last update: Christoph.elfmann