FtsZ

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• Description: cell-division initiation protein (septum formation) <br/><br/>

Gene name	ftsZ
Synonyms	ts-1
Essential	yes PubMed
Product	cell-division initiation protein (septum formation)
Function	formation of Z-ring
MW, pI	40 kDa, 4.814
Gene length, protein length	1146 bp, 382 aa
Immediate neighbours	ftsA, bpr
Get the DNA and protein sequences <br/> (Barbe et al., 2009)
Genetic context <br/> <div align="right"> <small>This image was kindly provided by SubtiList</small></div>

<br/><br/>

The gene

Basic information

• Locus tag: BSU15290

Phenotypes of a mutant

essential PubMed

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: ftsZ family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity: Z ring formation is inhibited upon binding of MciZ to FtsZ

• Interactions: FtsZ-ZapA PubMed, FtsZ-EzrA PubMed, FtsZ-SpoIIE, FtsZ-FtsA, FtsZ-FtsZ PubMed, MciZ-FtsZ PubMed, FtsZ-SepF

• Localization:
  • septal at the cell membrane PubMed
  • septal localization partially depends on the proton motive force PubMed

Database entries

• Structure: 2VAM, 2RHL (dimer with GDP)

• UniProt: P17865

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: ftsA-ftsZ PubMed

• Sigma factor: SigA PubMed, SigH PubMed

• Regulation: activated by WalR PubMed
  • repressed during logrithmic growth (AbrB) PubMed

• Regulatory mechanism:
  • AbrB: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: available in the Jeff Errington lab

Labs working on this gene/protein

Imrich Barak, Slovak Academy of Science, Bratislava, Slovakia homepage

References

Reviews

<pubmed> 19680248 19884039 17506674 15037301 </pubmed>

FtsZ as antibacterial drug target

<pubmed> 19583568 20410587 ,16174771, 20212044 20615583 </pubmed>

Other original Publications

<pubmed> 15288790, 15317782,12180929, 9364910,10323866, 19212404,15942012, 12007411,16420366, 16159787,10747015, 16796675,10322023,9495766,9287012,1569582,10878122,11395470,10449747,17662947,12368265,18284588,8600030,18588879,7592498, 19136590 , 19429628, 19141479 19843223 16484179 20199598 20566861 20711458 20807205 20933427 </pubmed>