Sandbox

• Description: D-alanyl-aminopeptidase
  
  

Gene name	dppA
Synonyms	dciAA
Essential	no
Product	D-alanyl-aminopeptidase
Function	degradation of cell wall peptides
MW, pI	30 kDa, 5.19
Gene length, protein length	822 bp, 274 aa
Immediate neighbours	proG, dppB
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU12920

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: peptidase M55 family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification: phosphorylated on ser/ thr/ tyr PubMed

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure: 1HI9

• Swiss prot entry: P26902

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: dppA-dppB-dppC-dppD-dppE PubMed

• Sigma factor: SigA PubMed

• Regulation: repressed during logrithmic growth (AbrB) [4] repressed by glucose (2.9-fold) PubMed, expressed postexponentially (AbrB) PubMed, repressed by CodY PubMed

• Regulatory mechanism: AbrB: transcription repression AbrB: transcription repression PubMed, CodY: transcription repression PubMed1 PubMed2

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

1. Blencke et al. (2003) Transcriptional profiling of gene expression in response to glucose in Bacillus subtilis: regulation of the central metabolic pathways. Metab Eng. 5: 133-149 PubMed
2. Lévine et al. (2006) Analysis of the dynamic Bacillus subtilis Ser/Thr/Tyr phosphoproteome implicated in a wide variety of cellular processes. Proteomics 6: 2157-2173 PubMed
3. Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed