RocA

• Description: 3-hydroxy-1-pyrroline-5-carboxylate dehydrogenase
  
  

Gene name	rocA
Synonyms	ipa-76d
Essential	no
Product	3-hydroxy-1-pyrroline-5-carboxylate dehydrogenase
Function	arginine, ornithine and citrulline utilization
MW, pI	56 kDa, 5.58
Gene length, protein length	1545 bp, 515 aa
Immediate neighbours	rocB, rocG
Gene sequence (+200bp)	Protein sequence
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Coordinates:

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification: phosphorylation on (Thr-2 OR Thr-4 OR Tyr-5) PubMed

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• Swiss prot entry:

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: rocA-rocB-rocC PubMed

• Sigma factor: SigL PubMed

• Regulation: induction by arginine (RocR) PubMed

• Regulatory mechanism: RocR: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

1. Calogero S, Gardan R, Glaser P, Schweizer J, Rapoport G, Debarbouille M. (1994) RocR, a novel regulatory protein controlling arginine utilization in Bacillus subtilis, belongs to the NtrC/NifA family of transcriptional activators. J. Bacteriol. volume: page-page. PubMed
2. Macek et al. (2007) The serine/ threonine/ tyrosine phosphoproteome of the model bacterium Bacillus subtilis. Mol. Cell. Proteomics 6: 697-707 PubMed
3. Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed